A Cardiac Ultrasound Evaluation of Two Types of Weaning Trials of Mechanical Ventilation for a First Weaning Trial

Completed

• Conditions: Critical Care; Trans-thoracic Echocardiography; Mitral Doppler; Diastolic Function; Weaning of Mechanical Ventilation
• Interventions: Other: trans thoracic echocardiography

• Registration Number: NCT02138903
• Lead Sponsor: University Hospital, Clermont-Ferrand

Brief Summary

Comparing the hemodynamic and cardiac effects of two types of weaning trials of mechanical ventilation in ICU patients of two French ICU.

Detailed Description

Prospective clinical study in ICU with ventilated patients eligible to weaning trials of mechanical ventilation (ZEEP and tubing-spontaneous ventilation) comparing hemodynamic and cardiac effects evaluated by trans-thoracic echocardiography.

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-04-11
• Study First Submitted QC: 2014-05-13
• Study First Posted: 2014-05-15
• Status Verified: 2014-11
• Primary Completion: 2014-11
• Study Completion: 2014-11
• Last Update Submitted: 2014-11-28
• Last Update Posted: 2014-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Adult patients ventilated requiring first weaning trial of mechanical ventilation

  • Stable respiratory and hemodynamic conditions
  • Consent of patients or family
  • Arterial line
  • Ventilated patients

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ZEEP and tubing-spontaneous ventilation	trans thoracic echocardiography	Prospective clinical study in ICU with ventilated patients eligible to weaning trials of mechanical ventilation (ZEEP and tubing-spontaneous ventilation) comparing hemodynamic and cardiac effects evaluated by trans-thoracic echocardiography.
trans-thoracic echocardiography	trans thoracic echocardiography	Prospective clinical study in ICU with ventilated patients eligible to weaning trials of mechanical ventilation (ZEEP and tubing-spontaneous ventilation) comparing hemodynamic and cardiac effects evaluated by trans-thoracic echocardiography.

Primary Outcome Measures

Name	Time	Method
left ventricular filling pressure	after 1 hour	Echo-cardiographic evaluation is realized at the end of the weaning trial (1 hour) or less if failed

Secondary Outcome Measures

Name	Time	Method
Comparison of other echocardiographic parameters of left ventricular filling pressures	after 1 hour	Comparison of other echocardiographic parameters of left ventricular filling pressures (E, Ea, deceleration time) at the end of weaning trial

Trial Locations

Locations (1)

CHU de Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France