Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline

Not Applicable

Recruiting

• Conditions: Mild Cognitive Impairment; Subjective Cognitive Decline

• Registration Number: NCT06281652
• Lead Sponsor: University of Milano Bicocca

Brief Summary

The goal of this clinical trial\]is to evaluate if learning to play traditional board games could improve cognition in subjects with mild cognitive impairment and subjective cognitive decline. The main questions it aims to answer are:

* Do Go and Chess improve cognition?

* Is a game better than the other? Is the effect of both games on cognition synergistic?

* Do Go and Chess improve quality of life?

* Do Go and Chess improve mood?

* Do Go and Chess improve lifestyle?

Participants will be randomized to one of four groups:

* Group intervention with Go, once a week, for 12 weeks

* Group intervention with Chess, once a week, for 12 weeks

* Group intervention with Go and Chess, twice a week, for 12 weeks

* Control group

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-02
• Study Start: 2024-02-13
• Study First Submitted: 2024-02-19
• Study First Submitted QC: 2024-02-19
• Study First Posted: 2024-02-28
• Last Update Submitted: 2024-02-29
• Last Update Posted: 2024-03-01
• Primary Completion: 2025-02-13
• Study Completion: 2025-02-13

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Diagnosis of mild cognitive impairment or subjective cognitive decline
• Willingness to participate in the board games classes
• Living within 20-minute driving distance from the center
• Signed informed consent

Exclusion Criteria

• Prior knowledge of the the game rules (in case the subject knows one of the two, they can be randomized to the other one)
• Significant linguistic or sensory impairment (according to clinical judgment)
• Significant behavioral or psychiatric disturbances (according to clinical judgment)
• Significant medical comorbidities (according to clinical judgment)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
General cognition	12 weeks	Differences in Montreal Cognitive Assessment between groups \[continuous scale, 0-30, higher scores indicate better performances\]

Secondary Outcome Measures

Name	Time	Method
Digit Span Backwards	12 weeks	Differences in Digit Span Backwards between groups \[continuous scale, 0-9, higher scores indicate better performances\]
Semantic fluency	12 weeks	Differences in Semantic fluency between groups \[continuous scale, min 0, max N/A, higher scores indicate better performances\]
Quality of life indicator	12 weeks	Differences in WHO Quality of life (WHO-QoL) scale between groups \[continuous scale, min 0 max 100, higher scores indicate better quality of life\]
Digit Span Forward	12 weeks	Differences in Digit Span Forward between groups \[continuous scale, 0-9, higher scores indicate better performances\]
Trail Making Test - part B	12 weeks	Differences in Trail Making Test - part B between groups \[time to complete the task, min 0 seconds, max N/A, higher scores indicate worse performances\]
Trail Making Test - part A	12 weeks	Differences in Trail Making Test - part A between groups \[time to complete the task, min 0 seconds, max N/A, higher scores indicate worse performances\]
Depression	12 weeks	Differences in geriatric depression scale scale between groups \[continuous scale, min 0 max 15, higher scores indicate worse depression\]
Lifestyle	12 weeks	Differences in simple lifestyle indicator questionnaire scale between groups \[continuous scale, min 0 max 10, higher scores indicate healthier lifestyle\]

Trial Locations

Locations (1)

Fondazione IRCCS San Gerardo dei Tintori; 🇮🇹 Monza, Lombardia, Italy