A Case Control Study of Patients With Diagnosis of Malignant Hyperthermia
- Conditions
- Malignant Hyperthermia
- Registration Number
- NCT02561598
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Brief Summary
The purpose of the study is to develop methods to identify predictors of Malignant Hyperthermia.
- Detailed Description
The current study will use the combination of electronic medical records and genomic information in samples of persons who have exhibited signs of Malignant Hyperthermia (MH) or have family history or high risk of MH to see if risk factors can be identified. These will be compared with control samples of children who have been exposed to the same agents which could induce MH, yet showed no signs of the disorder.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Malignant hyperthermia cases: Diagnosis of malignant hyperthermia
- Control cases: children who participated
- Not meeting the inclusion criteria stated above
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of clinical manifestations of malignant hyperthermia Within data collection period (3 years total). Incidence of clinical manifestations of MH will be compared among patients with a history of MH to controls (no diagnosis of MH).
- Secondary Outcome Measures
Name Time Method number of Genetic indications for malignant hyperthermia Within data collection period (3 years total). genetic indications for malignant hyperthermia will be compared between control subjects and subjects with a diagnosis of MH
Trial Locations
- Locations (1)
Cincinnati Children's Hospital Medical Center
🇺🇸Cincinnati, Ohio, United States