An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)
- Conditions
- Non-Small Cell Lung Cancer
- Interventions
- Registration Number
- NCT02477826
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
The purpose of this study is to show that Nivolumab, or Nivolumab plus Ipilimumab, or Nivolumab plus Platinum-Doublet Chemotherapy improves progression free survival and/or overall survival compared with chemotherapy in patients with advanced lung cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2748
- Subjects with histologically confirmed Stage IV or recurrent NSCLC squamous or non-squamous histology, with no prior systemic anticancer therapy
- Subjects must have programmed death-ligand 1 (PD -L1) immunohistochemical (IHC) testing, with results, performed by the central lab during the Screening period
- Eastern Cooperative Oncology Group (ECOG) Performance Status of โค 1
- Measurable disease by CT or MRI per response evaluation criteria in solid tumors version 1.1 (RECIST 1.1) criteria
- Subjects with untreated Central nervous system (CNS) metastases are excluded
- Subjects with an active, known or suspected autoimmune disease are excluded
- Any positive test for hepatitis B virus or hepatitis C virus or human immunodeficiency virus (HIV) indicating acute or chronic infection
Other protocol defined inclusion/exclusion criteria apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm B: Nivolumab + Ipilimumab Ipilimumab Nivolumab + Ipilimumab IV as specified Arm D: Platinum doublet chemotherapy Gemcitabine Chemotherapy administered on specified days of IV chemotherapy Arm D: Platinum doublet chemotherapy Paclitaxel Chemotherapy administered on specified days of IV chemotherapy Arm A: Nivolumab Nivolumab Nivolumab intravenously (IV) as specified Arm C: Nivolumab + Platinum doublet chemotherapy Nivolumab Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm D: Platinum doublet chemotherapy Carboplatin Chemotherapy administered on specified days of IV chemotherapy Arm D: Platinum doublet chemotherapy Pemetrexed Chemotherapy administered on specified days of IV chemotherapy Arm C: Nivolumab + Platinum doublet chemotherapy Paclitaxel Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm B: Nivolumab + Ipilimumab Nivolumab Nivolumab + Ipilimumab IV as specified Arm C: Nivolumab + Platinum doublet chemotherapy Cisplatin Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm C: Nivolumab + Platinum doublet chemotherapy Carboplatin Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm C: Nivolumab + Platinum doublet chemotherapy Gemcitabine Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm C: Nivolumab + Platinum doublet chemotherapy Pemetrexed Nivolumab + Platinum doublet chemotherapy (IV) dose as specified Arm D: Platinum doublet chemotherapy Cisplatin Chemotherapy administered on specified days of IV chemotherapy
- Primary Outcome Measures
Name Time Method Overall survival (OS) approximately 48 months Progression-free Survival (PFS) as determined by blinded independent central review (BICR) approximately 40 months
- Secondary Outcome Measures
Name Time Method Disease related symptom improvement as measured by the Lung Cancer Symptom Score (LCSS) in all subjects Up to 48 months Disease related symptom improvement assessed at each dosing for 6 months, then every 6 weeks while on treatment
Objective response rate (ORR) Up to 48 months ORR of nivolumab monotherapy and nivolumab in combination with ipilimumab to platinum-doublet chemotherapy in subjects with advanced lung cancer
Trial Locations
- Locations (290)
Local Institution - 0017
๐บ๐ธSan Francisco, California, United States
Local Institution - 0115
๐บ๐ธSaint Louis, Missouri, United States
Local Institution - 0014
๐บ๐ธCleveland, Ohio, United States
Local Institution - 0075
๐บ๐ธLanghorne, Pennsylvania, United States
Local Institution - 0083
๐ฎ๐นMilan, Lombardia, Italy
Local Institution - 0179
๐ฎ๐นBergamo, Italy
Local Institution - 0087
๐ฎ๐นPerugia, Italy
Local Institution - 0085
๐ฎ๐นTerni, Italy
Southern Cancer Center, Inc.
๐บ๐ธMobile, Alabama, United States
Local Institution - 0021
๐บ๐ธNew Haven, Connecticut, United States
Local Institution - 0001
๐บ๐ธAtlanta, Georgia, United States
Local Institution - 0013
๐บ๐ธMarietta, Georgia, United States
Local Institution - 0004
๐บ๐ธLexington, Kentucky, United States
Local Institution - 0005
๐บ๐ธBuffalo, New York, United States
Local Institution - 0019
๐บ๐ธNew York, New York, United States
Local Institution - 0009
๐บ๐ธColumbus, Ohio, United States
Local Institution - 0007
๐บ๐ธAllentown, Pennsylvania, United States
Local Institution - 0299
๐บ๐ธPhiladelphia, Pennsylvania, United States
Local Institution - 0012
๐บ๐ธPhiladelphia, Pennsylvania, United States
Local Institution - 0015
๐บ๐ธSayre, Pennsylvania, United States
Local Institution - 0008
๐บ๐ธCharleston, South Carolina, United States
Local Institution - 0080
๐บ๐ธGreenville, South Carolina, United States
Local Institution - 0306
๐บ๐ธDallas, Texas, United States
Local Institution - 0003
๐บ๐ธDallas, Texas, United States
Local Institution - 0010
๐บ๐ธGreenville, South Carolina, United States
Local Institution - 0020
๐บ๐ธNashville, Tennessee, United States
Local Institution - 0102
๐บ๐ธHouston, Texas, United States
Local Institution - 0011
๐บ๐ธSalt Lake City, Utah, United States
Local Institution - 0074
๐บ๐ธKennewick, Washington, United States
Local Institution - 0170
๐ฆ๐ทBerazategui, Buenos Aires, Argentina
Local Institution - 0171
๐ฆ๐ทCapital Federal, Buenos Aires, Argentina
Local Institution - 0172
๐ฆ๐ทCiudad Autonoma De Buenos Aire, Buenos Aires, Argentina
Local Institution - 0176
๐ฆ๐ทCiudad de Buenos Aires, Buenos Aires, Argentina
Local Institution - 0296
๐ฆ๐ทMar Del Plata, Buenos Aires, Argentina
Local Institution - 0177
๐ฆ๐ทViedma, RIO Negro, Argentina
Local Institution - 0130
๐ฆ๐ทSan Miguel de Tucuman, Tucuman, Argentina
Local Institution - 0268
๐ฆ๐ทCordoba, Argentina
Local Institution - 0272
๐ฆ๐ทCรณrdoba, Argentina
Local Institution - 0297
๐ฆ๐ทCรณrdoba, Argentina
Local Institution - 0182
๐ฆ๐บGarran, Australian Capital Territory, Australia
Local Institution - 0301
๐ฆ๐บBlacktown, New South Wales, Australia
Local Institution - 0300
๐ฆ๐บGosford, New South Wales, Australia
Local Institution - 0045
๐ฆ๐บBrisbane, Queensland, Australia
Local Institution - 0046
๐ฆ๐บElizabeth Vale, South Australia, Australia
Local Institution - 0043
๐ฆ๐บClayton, Victoria, Australia
Local Institution - 0042
๐ฆ๐บFitzroy, Victoria, Australia
Local Institution - 0180
๐ฆ๐บPerth, Western Australia, Australia
Local Institution - 0040
๐ฆ๐บMurdoch, Australia
Local Institution - 0183
๐ฆ๐บNorth Tamworth, Australia
Local Institution - 0241
๐ฆ๐นGraz, Austria
Local Institution - 0240
๐ฆ๐นVienna, Austria
Local Institution - 0239
๐ฆ๐นWels, Austria
Local Institution - 0121
๐ง๐ชRoeselare, West-Vlaanderen, Belgium
Local Institution - 0030
๐ง๐ชEdegem, Belgium
Local Institution - 0031
๐ง๐ชGent, Belgium
Local Institution - 0034
๐ง๐ชGilly, Belgium
Local Institution - 0117
๐ง๐ชHasselt, Belgium
Local Institution - 0033
๐ง๐ชSint Niklaas, Belgium
Local Institution - 0125
๐ง๐ทSalvador, Bahia, Brazil
Local Institution - 0124
๐ง๐ทIjui, RIO Grande DO SUL, Brazil
Local Institution - 0123
๐ง๐ทPorto Alegre, Rio Grande Do Sul, Brazil
Local Institution - 0127
๐ง๐ทBarretos, Sao Paulo, Brazil
Local Institution - 0129
๐ง๐ทRio De Janeiro, Brazil
Local Institution - 0144
๐ง๐ทSao Paulo, Brazil
Local Institution - 0126
๐ง๐ทSao Paulo, Brazil
Local Institution - 0128
๐ง๐ทSao Paulo, Brazil
Local Institution - 0103
๐จ๐ฆEdmonton, Alberta, Canada
Local Institution - 0290
๐จ๐ฆSt. John's, Newfoundland and Labrador, Canada
Local Institution - 0104
๐จ๐ฆLondon, Ontario, Canada
Local Institution - 0122
๐จ๐ฆMontreal, Quebec, Canada
Local Institution - 0106
๐จ๐ฆQuebec City, Quebec, Canada
Local Institution - 0107
๐จ๐ฆRimouski, Quebec, Canada
Local Institution - 0291
๐จ๐ฆSherbrooke, Quebec, Canada
Local Institution - 0292
๐จ๐ฆTrois-Rivieres, Quebec, Canada
Local Institution - 0302
๐จ๐ฆQuebec, Canada
Local Institution - 0173
๐จ๐ฑSantiago, Metropolitana, Chile
Local Institution - 0131
๐จ๐ฑSantiago, Regiรณn Metropolitana De Santiago, Chile
Local Institution - 0174
๐จ๐ฑVina Del Mar, Valparaiso, Chile
Local Institution - 0380
๐จ๐ณHefei, Anhui, China
Local Institution - 0313
๐จ๐ณBeijing, Beijing, China
Local Institution - 0315
๐จ๐ณBeijing, Beijing, China
Local Institution - 0316
๐จ๐ณBeijing, Beijing, China
Local Institution - 0314
๐จ๐ณBeijing, Beijing, China
Local Institution - 0365
๐จ๐ณChongqing, Chongqing, China
Local Institution - 0364
๐จ๐ณChongqing, Chongqing, China
Local Institution - 0378
๐จ๐ณChongqing, Chongqing, China
Local Institution - 0322
๐จ๐ณGuangzhou, Guangdong, China
Local Institution - 0372
๐จ๐ณGuangzhou, Guangdong, China
Local Institution - 0319
๐จ๐ณGuanzhou, Guangdong, China
Local Institution - 0323
๐จ๐ณHaikou, Hainan, China
Local Institution - 0325
๐จ๐ณHaerbin, Heilongjiang, China
Local Institution - 0324
๐จ๐ณZhengzhou, Henan, China
Local Institution - 0379
๐จ๐ณZhengzhou, Henan, China
Local Institution - 0375
๐จ๐ณWuhan, Hubei, China
Local Institution - 0362
๐จ๐ณChangsha, Hunan, China
Local Institution - 0347
๐จ๐ณNanchang, Jiangxi, China
Local Institution - 0329
๐จ๐ณChangchun, Jilin, China
Local Institution - 0361
๐จ๐ณChangchun, Jilin, China
Local Institution - 0359
๐จ๐ณShenyang, Liaoning, China
Local Institution - 0371
๐จ๐ณXi'an, Shaanxi, China
Local Institution - 0333
๐จ๐ณXi'an, Shan3xi, China
Local Institution - 0360
๐จ๐ณQingdao, Shandong, China
Local Institution - 0334
๐จ๐ณShanghai, Shanghai, China
Local Institution - 0373
๐จ๐ณTianjin, Tianjin, China
Local Institution - 0376
๐จ๐ณChengdu, Sichuan, China
Local Institution - 0340
๐จ๐ณUrumqi, Xinjiang, China
Local Institution - 0343
๐จ๐ณHangzhou, Zhejiang, China
Local Institution - 0342
๐จ๐ณHangzhou, Zhejiang, China
Local Institution - 0370
๐จ๐ณHangzhou, Zhejiang, China
Local Institution - 0328
๐จ๐ณChangsha, China
Local Institution - 0341
๐จ๐ณHangzhou, China
Local Institution - 0345
๐จ๐ณKunming, China
Local Institution - 0336
๐จ๐ณShanghai, China
Local Institution - 0337
๐จ๐ณShanghai, China
Local Institution - 0374
๐จ๐ณShantou, China
Local Institution - 0273
๐จ๐ดPereira, Risaralda, Colombia
Local Institution - 0237
๐จ๐ดBogota, Colombia
Local Institution - 0238
๐จ๐ดBogota, Colombia
Local Institution - 0282
๐จ๐ดMedellin, Colombia
Local Institution - 0112
๐จ๐ฟHradec Kralove, Czechia
Local Institution - 0113
๐จ๐ฟOlomouc, Czechia
Local Institution - 0111
๐จ๐ฟPraha 4, Czechia
Local Institution - 0232
๐จ๐ฟPribram, Czechia
Local Institution - 0270
๐ซ๐ฎOulu, Finland
Local Institution - 0271
๐ซ๐ฎTurku, Finland
Local Institution - 0222
๐ซ๐ทBron, Rhรดne, France
Local Institution - 0216
๐ซ๐ทANGERS Cedex 2, France
Local Institution - 0229
๐ซ๐ทBesanรงon Cedex, France
Local Institution - 0283
๐ซ๐ทCaen, France
Local Institution - 0218
๐ซ๐ทCreteil, France
Local Institution - 0228
๐ซ๐ทLimoges, France
Local Institution - 0230
๐ซ๐ทParis, France
Local Institution - 0215
๐ซ๐ทMarseille Cedex 20, France
Local Institution - 0227
๐ซ๐ทPessac, France
Local Institution - 0223
๐ซ๐ทRennes, France
Local Institution - 0225
๐ซ๐ทRouen, France
Local Institution - 0221
๐ซ๐ทSaint Priest En Jarez, France
Local Institution - 0217
๐ซ๐ทSaint-herblain Cedex, France
Local Institution - 0224
๐ซ๐ทStrasbourg, France
Local Institution - 0226
๐ซ๐ทToulon, France
Local Institution - 0231
๐ฉ๐ชMagdeburg, Sachsen-Anhalt, Germany
Local Institution - 0213
๐ฉ๐ชBad Berka, Germany
Local Institution - 0208
๐ฉ๐ชBerlin, Germany
Local Institution - 0205
๐ฉ๐ชEssen, Germany
Local Institution - 0210
๐ฉ๐ชFrankfurt, Germany
Local Institution - 0211
๐ฉ๐ชGera, Germany
Local Institution - 0203
๐ฉ๐ชGrosshansdorf, Germany
Local Institution - 0209
๐ฉ๐ชHalle, Germany
Local Institution - 0202
๐ฉ๐ชHeidelberg, Germany
Local Institution - 0214
๐ฉ๐ชHemer, Germany
Local Institution - 0206
๐ฉ๐ชImmenstadt, Germany
Local Institution - 0204
๐ฉ๐ชMuenchen, Germany
Local Institution - 0201
๐ฉ๐ชStuttgart, Germany
Local Institution - 0212
๐ฉ๐ชWiesbaden, Germany
Local Institution - 0094
๐ฌ๐ทAthens, Attikรญ, Greece
Local Institution - 0095
๐ฌ๐ทHeraklion, Greece
Local Institution - 0190
๐ฌ๐ทNeo Faliro, Greece
Local Institution - 0101
๐ฌ๐ทThessaloniki, Greece
Local Institution - 0025
๐ญ๐บBudapest, Hungary
Local Institution - 0024
๐ญ๐บBudapest, Hungary
Local Institution - 0026
๐ญ๐บMatrahaza, Hungary
Local Institution - 0054
๐ฎ๐ชDublin 8, Dublin, Ireland
Local Institution - 0053
๐ฎ๐ชBeaumont, Ireland
Local Institution - 0055
๐ฎ๐ชGalway, Ireland
Local Institution - 0100
๐ฎ๐ชLimerick, Ireland
Local Institution - 0187
๐ฎ๐ฑJerusalem, Israel
Local Institution - 0186
๐ฎ๐ฑKfar-saba, Israel
Local Institution - 0185
๐ฎ๐ฑPetach Tikva, Israel
Local Institution - 0184
๐ฎ๐ฑTel-hashomer, Israel
Local Institution - 0188
๐ฎ๐ฑZerifin, Israel
Azienda Ospedaliera Moscati
๐ฎ๐นAvellino, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
๐ฎ๐นBologna, Italy
Local Institution - 0084
๐ฎ๐นLivorno, Italy
Policlinico G. Martino
๐ฎ๐นMessina, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
๐ฎ๐นMilan, Italy
Istituto Nazionale Tumori Fondazione Pascale
๐ฎ๐นNapoli, Italy
Ospedale Santa Maria delle Croci
๐ฎ๐นRavenna, Italy
Ifo-Istituto Regina Elena
๐ฎ๐นRoma, Italy
Local Institution - 0089
๐ฎ๐นRoma, Italy
Local Institution - 0153
๐ฏ๐ตNagoya-shi, Aichi, Japan
Local Institution - 0152
๐ฏ๐ตNagoya, Aichi, Japan
Local Institution - 0148
๐ฏ๐ตKashiwa-shi, Chiba, Japan
Local Institution - 0159
๐ฏ๐ตMatsuyama, Ehime, Japan
Local Institution - 0160
๐ฏ๐ตFukuoka-shi, Fukuoka, Japan
Local Institution - 0259
๐ฏ๐ตKurume-shi, Fukuoka, Japan
Local Institution - 0255
๐ฏ๐ตOta-shi, Gunma, Japan
Local Institution - 0258
๐ฏ๐ตHiroshima-shi, Hiroshima, Japan
Local Institution - 0163
๐ฏ๐ตSapporo-shi, Hokkaido, Japan
Local Institution - 0253
๐ฏ๐ตSapporo-shi, Hokkaido, Japan
Local Institution - 0252
๐ฏ๐ตAkashi-shi, Hyogo, Japan
Local Institution - 0156
๐ฏ๐ตKobe-shi, Hyogo, Japan
Local Institution - 0146
๐ฏ๐ตKanazawa-shi, Ishikawa, Japan
Local Institution - 0161
๐ฏ๐ตYokohama-shi, Kanagawa, Japan
Local Institution - 0150
๐ฏ๐ตYokohama-Shi, Kanagawa, Japan
Local Institution - 0275
๐ฏ๐ตNatori-shi, Miyagi, Japan
Local Institution - 0254
๐ฏ๐ตSendai-shi, Miyagi, Japan
Local Institution - 0145
๐ฏ๐ตSendai-shi, Miyagi, Japan
Local Institution - 0164
๐ฏ๐ตNiigata-shi, Niigata, Japan
Local Institution - 0158
๐ฏ๐ตKurashiki-shi, Okayama, Japan
Local Institution - 0155
๐ฏ๐ตHirakata-shi, Osaka, Japan
Local Institution - 0154
๐ฏ๐ตOsaka-shi, Osaka, Japan
Local Institution - 0251
๐ฏ๐ตOsakasayama-shi, Osaka, Japan
Local Institution - 0257
๐ฏ๐ตTakatsuki-shi, Osaka, Japan
Local Institution - 0353
๐ฏ๐ตHidaka-shi, Saitama, Japan
Local Institution - 0256
๐ฏ๐ตKitaadachi-gun, Saitama, Japan
Local Institution - 0151
๐ฏ๐ตSunto-gun, Shizuoka, Japan
Local Institution - 0147
๐ฏ๐ตChuo-ku, Tokyo, Japan
Local Institution - 0149
๐ฏ๐ตKoto-ku, Tokyo, Japan
Local Institution - 0278
๐ฏ๐ตShinjuku-ku, Tokyo, Japan
Local Institution - 0157
๐ฏ๐ตWakayama-shi, Wakayama, Japan
Local Institution - 0354
๐ฏ๐ตUbe-shi, Yamaguchi, Japan
Local Institution - 0260
๐ฏ๐ตChiba, Japan
Local Institution - 0165
๐ฏ๐ตOkayama, Japan
Local Institution - 0162
๐ฏ๐ตTokyo, Japan
Local Institution - 0136
๐ฐ๐ทSeongnam-si, Kyวnggi-do, Korea, Republic of
Local Institution - 0249
๐ฐ๐ทCheongju-si, Korea, Republic of
Local Institution - 0133
๐ฐ๐ทGangnam-gu, Korea, Republic of
Local Institution - 0132
๐ฐ๐ทSeoul, Korea, Republic of
Local Institution - 0135
๐ฐ๐ทSeoul, Korea, Republic of
Local Institution - 0287
๐ฑ๐งBeirut, Lebanon
Local Institution - 0286
๐ฑ๐งBeirut, Lebanon
Local Institution - 0196
๐ฒ๐ฝDf, Distrito Federal, Mexico
Local Institution - 0193
๐ฒ๐ฝMexico, Distrito Federal, Mexico
Local Institution - 0198
๐ฒ๐ฝCuautitlan, Estado DE Mexico, Mexico
Local Institution - 0197
๐ฒ๐ฝGuadalajara, Jalisco, Mexico
Local Institution - 0191
๐ฒ๐ฝZapopan, Jalisco, Mexico
Local Institution - 0267
๐ฒ๐ฝMorelia, Michoacan, Mexico
Local Institution - 0277
๐ฒ๐ฝMonterrey, Nuevo Leon, Mexico
Local Institution - 0303
๐ฒ๐ฝMerida, Yucatรกn, Mexico
Local Institution - 0192
๐ฒ๐ฝChihuahua, Mexico
Local Institution - 0195
๐ฒ๐ฝSan Luis Potosi, Mexico
Local Institution - 0236
๐ฒ๐ฝSan Luis Potosi, Mexico
Local Institution - 0194
๐ฒ๐ฝToluca, Mexico
Local Institution - 0036
๐ณ๐ฑAmsterdam, Netherlands
Local Institution - 0189
๐ณ๐ฑAmsterdam, Netherlands
Local Institution - 0169
๐ณ๐ฑBreda, Netherlands
Local Institution - 0037
๐ณ๐ฑRotterdam, Netherlands
Local Institution - 0039
๐ณ๐ฑVeldhoven, Netherlands
Local Institution - 0262
๐ต๐ชLima, Peru
Local Institution - 0263
๐ต๐ชLima, Peru
Local Institution - 0350
๐ต๐ชLima, Peru
Local Institution - 0261
๐ต๐ชLima, Peru
Local Institution - 0351
๐ต๐ชLima, Peru
Local Institution - 0060
๐ต๐ฑBydgoszcz, Poland
Local Institution - 0058
๐ต๐ฑGdansk, Poland
Local Institution - 0063
๐ต๐ฑGdynia, Poland
Local Institution - 0072
๐ต๐ฑGliwice, Poland
Local Institution - 0057
๐ต๐ฑLodz, Poland
Local Institution - 0059
๐ต๐ฑWarszawa, Poland
Local Institution - 0070
๐ต๐ฑWroclaw, Poland
Local Institution - 0167
๐ท๐ดCraiova, Romania
Local Institution - 0250
๐ท๐ดFloresti, Romania
Local Institution - 0166
๐ท๐ดRomania, Romania
Local Institution - 0284
๐ท๐ดSector 2, Romania
Local Institution - 0137
๐ท๐บChelyabinsk, Russian Federation
Local Institution - 0142
๐ท๐บKazan, Russian Federation
Local Institution - 0022
๐ท๐บMoscow, Russian Federation
Local Institution - 0049
๐ท๐บSaint-Petersburg, Russian Federation
Local Institution - 0028
๐ท๐บSt. Petersburg, Russian Federation
Local Institution - 0027
๐ท๐บSt. Petersburg, Russian Federation
Local Institution - 0143
๐ท๐บUfa, Russian Federation
Local Institution - 0264
๐ฟ๐ฆPretoria, Gauteng, South Africa
Local Institution - 0234
๐ฟ๐ฆSandton, Gauteng, South Africa
Local Institution - 0233
๐ฟ๐ฆSaxonwold, Johannesburg, Gauteng, South Africa
Local Institution - 0305
๐ฟ๐ฆVereeniging, South Africa
Local Institution - 0064
๐ช๐ธMajadahonda, Madrid, Spain
Local Institution - 0066
๐ช๐ธBarcelona, Spain
Local Institution - 0067
๐ช๐ธBarcelona, Spain
Local Institution - 0065
๐ช๐ธMadrid, Spain
Local Institution - 0068
๐ช๐ธValencia, Spain
Local Institution - 0069
๐ช๐ธSevilla, Spain
Local Institution - 0243
๐จ๐ญBasel, Switzerland
Local Institution - 0246
๐จ๐ญChur, Switzerland
Local Institution - 0244
๐จ๐ญLausanne, Switzerland
Local Institution - 0245
๐จ๐ญWinterthur, Switzerland
Local Institution - 0139
๐จ๐ณTaichung, Taiwan
Local Institution - 0138
๐จ๐ณTaipei, Taiwan
Local Institution - 0140
๐จ๐ณTaipei, Taiwan
Local Institution - 0310
๐จ๐ณTaipei, Taiwan
Local Institution - 0141
๐จ๐ณTaoyuan city, Taiwan
Local Institution - 0266
๐ฌ๐งMiddlesborough, Cleveland, United Kingdom
Local Institution - 0098
๐ฌ๐งLondon, Greater London, United Kingdom
Local Institution - 0099
๐ฌ๐งSouthampton, Hampshire, United Kingdom
Local Institution - 0118
๐ฌ๐งLeicester, Leicestershire, United Kingdom
Local Institution - 0265
๐ฌ๐งBirmingham, United Kingdom
Local Institution - 0051
๐ฌ๐งCambridgeshire, United Kingdom
Local Institution - 0109
๐ฌ๐งEdinburgh, United Kingdom
Local Institution - 0097
๐ฌ๐งLondon, United Kingdom
Local Institution - 0050
๐ฌ๐งLondon, United Kingdom
Local Institution - 0119
๐ฌ๐งSurrey, United Kingdom