The effect of donor white blood cell filtration to prevent donor cell survival in transfused trauma patients
Not Applicable
Completed
- Conditions
- blood transfusion outcomesdonor cell survival (microchimerism)Blood - Other blood disorders
- Registration Number
- ACTRN12616001054404
- Lead Sponsor
- Australian Red Cross Blood Service
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
trauma patient ISS>12
Blood transfusion of 5 units or more in 4 hours or 10 units or more in 24 hours
Exclusion Criteria
Pregnancy
Minors under the age of 16
ISS<12
Previous blood transfusion prior to current injury
Patients with haematology condition
Mentally impaired who are not sound of mind to consent
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detection of long-term surviving donor white blood cell following blood transfusion assessed following quantitative real time polymerase chain reaction testing.[Retrospective study - up to 10 years following blood transfusion was given<br><br>Prospective study-<br>1)upon admission<br>2) 5-7 days following every blood transfusion episode<br>3) at discharge or every 30 days in hospital until discharge<br>4) every 6 months for a period of 36 months post discharge]
- Secondary Outcome Measures
Name Time Method Prospective study only -<br>Composite secondary outcome to analyse the immune response and cytokine profiles by cytometric bead array on plasma obtained from the blood sample and compared between patients who do or do not have microchimerism[1) upon admission<br>2) 5-7 days following every blood transfusion episode<br>3) at discharge or every 30 days in hospital until discharge<br>4) every 6 months for a period of 36 months post discharge]