Evaluation of the effects of levosimendan and Milrinone on the heart�s pumping effect in patients with impaired heart dysfunction undergoing coronary artery bypass surgery on bypass machine

Phase 3

Completed

• Conditions: Health Condition 1: I251- Atherosclerotic heart disease of native coronary arteryHealth Condition 2: I978- Other intraoperative and postprocedural complications and disorders of the circulatory system, not elsewhere classified

• Registration Number: CTRI/2021/07/035202
• Lead Sponsor: cmc Vellore fluid research grand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-12-15
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

1. Patients, between 40 and 70 years

2. Both sexes

3. Impaired left ventricular function (Ejection fraction � 40%), 4. Mean pulmonary artery pressure between 25-35 mmHg,

5. New York Heart Association (NYHA III & IV)

6. Undergoing elective On-Pump Coronary Artery Bypass Graft surgery

Exclusion Criteria

1. Geriatric patients (age over 70 years).

2. Patients with end-organ failure (renal, liver).

3. Perioperative surgical complications unrelated to the study (accidental surgical trauma to a nearby organ or massive blood loss defined as blood loss exceeding circulating blood volume within a 24-hour period due to surgical insult).

4. Associated mitral or aortic valve disease.

5. Preoperative requirement of inotropes or mechanical ventilation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified