Pilot study to evaluate the potential value of Fluorescence In Situ Hybridization (FISH) of white blood cells for the diagnosis of Q fever fatigue syndrome
Completed
- Conditions
- Q feverCoxiellosis10004018
- Registration Number
- NL-OMON52417
- Lead Sponsor
- Stichting Q-support
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 49
Inclusion Criteria
- At least 18 years old;
- Able and willing to sign the informed consent form;
- Known clinical Q fever history (absent for group A and B; Q fever fatigue
syndrome for group C; proven chronic Q fever for group D);
- Previous positive test for serological response to Coxiella burnetii (group
B-D) and negative serological and cellular response to Coxiella burnetii for
group A.
Exclusion Criteria
There are no specific criteria for subjects to be excluded from participation
in this study, as long as they adhere to the inclusion criteria mentioned
above.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Categorical FISH result (positive or negative, based on a pre-established<br /><br>cut-off of 5% positivity (3/50) among counted leukocytes). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Percentage of positively scored leukocytes per blood sample and fluorescent<br /><br>intensity of positively scored leukocytes.</p><br>