Brody's Syndrome: Clinical Aspects, Genetic Background, and Electrophysiological Properties

Completed

• Conditions: 10028302; Syndroom van Brody; 10028396

• Registration Number: NL-OMON40443
• Lead Sponsor: Radboudumc

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 105

Inclusion Criteria

Brody's Syndrome

Exclusion Criteria

Age < 18

For TMS part of protocol:
- pregnancy
- serious head trauma or brain surgery
- large or ferromagnetic metal parts in the head
- implanted cardiac pacemaker or neurostimulator
- epilepsy, convulsion or seizure
- use of medication that can influence muscle relaxation or cortical excitability

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Results from verious questionnaires<br /><br>2) Results from genetic analysis<br /><br>3) Relaxation time (ms) and rate (Nm/s) of the elbowflexors (using TMS) and m.<br /><br>interosseus dorsalis I (using electrical nerve stimulation)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Maximum force of elbowflexors and m. interosseus dorsalis I</p><br>