association between P.gingivalis strains in mouth and those in oral cancer and oesophageal cancer tissues
Not Applicable
Completed
- Conditions
- Health Condition 1: C159- Malignant neoplasm of esophagus, unspecifiedHealth Condition 2: C069- Malignant neoplasm of mouth, unspecified
- Registration Number
- CTRI/2020/04/024835
- Lead Sponsor
- INDIAN COUNCIL OF MEDICAL RESEARCH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients suffering from Oral Squamous Cell Carcinoma
Patients suffering from Oesophageal Squamous Cell Carcinoma
Patients who have not yet undergone any Surgical therapy/ Chemotherapy/ Radiotherapy for treatment of the carcinoma
Patients willing to give informed consent
Patients with minimum 20 teeth
Exclusion Criteria
Patients with any malignancy other than squamous cell carcinoma of the oral cavity/ esophagus
Patients undergoing any treatment for carcinoma or its recurrence
History of antibiotic use in the previous three months
Pregnant or lactating females
Patients who received periodontal treatment within the last 6 months
Patients who require antibiotic prophylaxis before examination
Patients unwilling to participate in the study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Arbitrarily primed polymerase chain reaction (AP-PCR) fingerprinting of P. gingivalis isolates from dental plaque, saliva, healthy and tumour tissue in patients with Oral/ Oesophageal cancersTimepoint: baseline
- Secondary Outcome Measures
Name Time Method Correlation of P. gingivalis strain with periodontal health statusTimepoint: baseline;Correlation of the prevalence rate of P.gingivalis in saliva with that in dental plaque samples and tumour tissuesTimepoint: baseline;Estimation of prevalence rate of P. gingivalis in healthy and tumour tissue of patients with Oral/ Oesophageal cancers using MALDI-TOF MS.Timepoint: baseline;Estimation of prevalence rate of P. gingivalis in saliva & dental plaque of patients with Oral/ Oesophageal cancers using MALDI-TOF MSTimepoint: baseline;To estimate the prevalence of Periodontal disease in patients suffering from Oral/ Oesophageal cancers by recording the Periodontal status of all subjects <br/ ><br> <br/ ><br> <br/ ><br> <br/ ><br> <br/ ><br>Timepoint: BASELINE