Apathy in patients with Parkinson*s disease and major depressive disorder, a structural brain imaging study using Voxel Based Morphometry
- Conditions
- pathological indifference1002930510027946
- Registration Number
- NL-OMON30824
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
- Idiopathic Parkinson*s disease as defined by the criteria of the United Kingdom Parkinson*s Disease Brain Bank, regarding the inclusion of Parkinson*s disease patients (Hughes, Daniel et al. 1992).
- Apathy as defined by a score equal or higher than four on the apathy subscale of the Neuro Psychiatric Inventory (NPI), regarding the apathy groups (Cummings, Mega et al. 1994; Cummings 1997).
- Depression as defined by the criteria stated in the DSM-IV, regarding the depressed patients (DSM-IV 1994).
- Informed consent.
- Other concurrent neurological diseases than PD.
- Concurrent psychiatric diseases (e.g. dementia).
- Use of psychopharmacological medication.
- Abuse of alcohol and/or drugs.
- Cognitive deterioration as operationalised by a score of <23 on the Mini Mental Status Examination (MMSE) (Folstein, Folstein et al. 1975).
Voxel Based Morphometry exclusion criteria:
- Pacemaker.
- Hart valve prosthesis.
- Metal fragments in brain or surrounding tissue.
- Ear implants.
- Claustrophobia.
- Infusion pumps.
- Pregnancy.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Atrophic brain processes observed in all groups (both grey matter atrophy and<br /><br>white matter hyper-intensities), measured by Voxel Based Morphometry imaging.<br /><br>- Performance on neuropsychiatric and neuropsychological tests.<br /><br>- Correlation between the abovementioned points.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>