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Clinical Trials/NL-OMON30824
NL-OMON30824
Completed
Not Applicable

Apathy in patients with Parkinson*s disease and major depressive disorder, a structural brain imaging study using Voxel Based Morphometry - Imaging and Apathy in patients with Parkinson*s disease

niversiteit Maastricht0 sites120 target enrollmentTBD
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Conditionspathological indifference1002930510027946

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
pathological indifference
Sponsor
niversiteit Maastricht
Enrollment
120
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Observational invasive

Investigators

Eligibility Criteria

Inclusion Criteria

  • •\- Idiopathic Parkinson\*s disease as defined by the criteria of the United Kingdom Parkinson\*s Disease Brain Bank, regarding the inclusion of Parkinson\*s disease patients (Hughes, Daniel et al. 1992\).
  • •\- Apathy as defined by a score equal or higher than four on the apathy subscale of the Neuro Psychiatric Inventory (NPI), regarding the apathy groups (Cummings, Mega et al. 1994; Cummings 1997\).
  • •\- Depression as defined by the criteria stated in the DSM\-IV, regarding the depressed patients (DSM\-IV 1994\).
  • •\- Informed consent.

Exclusion Criteria

  • •\- Other concurrent neurological diseases than PD.
  • •\- Concurrent psychiatric diseases (e.g. dementia).
  • •\- Use of psychopharmacological medication.
  • •\- Abuse of alcohol and/or drugs.
  • •\- Cognitive deterioration as operationalised by a score of \<23 on the Mini Mental Status Examination (MMSE) (Folstein, Folstein et al. 1975\).
  • •Voxel Based Morphometry exclusion criteria:
  • •\- Pacemaker.
  • •\- Hart valve prosthesis.
  • •\- Metal fragments in brain or surrounding tissue.
  • •\- Ear implants.

Outcomes

Primary Outcomes

Not specified

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