Obesity and the Initiation of Knee Osteoarthritis
Completed
- Conditions
- Obesity
- Registration Number
- NCT00856739
- Lead Sponsor
- US Department of Veterans Affairs
- Brief Summary
Healthy adults aged 20-60 of varying weights will participate in this minimally invasive study. There is one 4-hour appointment for which subjects are paid $120. The tests involve: 1 tube blood draw, 1 gait test (motion capture) and 1 MR of both knees.
- Detailed Description
The tests will be done at the VA and Stanford and are not dangerous or painful. They are designed to help us learn more about the relationship of excess weight on cartilage degradation by testing a biomarker in blood. Gait testing involves walking in a lab that is about 20 meters long about 20 times. MR involves lying in a tube for less than 1 hour.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 177
Inclusion Criteria
- Healthy Adults aged 20-60 who have no history of LE surgery
- Healthy adults able to walk 30 minutes
- Healthy adults able to have MR
Exclusion Criteria
- Adults who have had LE surgery
- Adults cannot walk 30 minutes
- Adults who cannot tolerate MR
- Adults with osteoarthritis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gait Knee Adduction Moment baseline or first and only visit. Cartilage Thickness baseline or first and only visit. Medial/lateral thickness ratio
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
VA Palo Alto Health Care System
🇺🇸Palo Alto, California, United States