Association of Haptoglobin 2-2 With Postoperative Delirium
- Conditions
- Postoperative Delirium
- Registration Number
- NCT03392480
- Lead Sponsor
- Sun Yat-sen University
- Brief Summary
Patients with major orthopedic surgery will be recruited. Participants will be monitored for delirium after surgery. Participants' blood will be harvested for the determination of haptoglobin types, levels of oxidative stress and inflammation. Investigators will then analyze the data to see if haptoglobin 2-2 type is associated with an increased postoperative delirium, inflammation and oxidative stress.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- American Society of Anesthesiologists physical status I to III class for major orthopedic surgery (hip or knee replacement or spinal surgery)
- No psychological and psychiatric history and presentation before surgery
- No major organ dysfunction or failure
- Anemia (hemoglobin < 100 g/l) preoperatively.
- Requires > 4 units of allogeneic red blood cell transfusion during the surgery
- Using steroids or anti-psychological and anti-psychiatric drugs. A small dose of steroid for postoperative anti-nausea/vomiting is allowed and will not be considered as a indication for exclusion.
- Can not cooperate with the study
- History of bleeding
- BMI < 18 or > 30
- History of hemoglobin metabolism disorder
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative delirium duration From day 0 to up to 7 days after the surgery The duration of delirium as assessed by intensive care unit-confusion assessment method will be determined.
Postoperative delirium incidence From day 0 to up to 7 days after the surgery The incidence of delirium as assessed by intensive care unit-confusion assessment method will be determined.
- Secondary Outcome Measures
Name Time Method Oxidative stress level Day 0 to day 2 after the surgery The level of malondialdehyde in the blood will be measured by ELISA.
Inflammation level Day 0 to day 2 after the surgery The levels of interleukin 1beta and interleukin 6 in the blood will be assessed by ELISA.
Trial Locations
- Locations (8)
Chinese PLA general hospital
🇨🇳Beijing, China
Xinqiao hospital, Army military medical university
🇨🇳Chongqing, China
Daping Hospital, Army Military Medical University
🇨🇳Chongqing, China
the First Affiliated Hospital of Southern Medical University
🇨🇳Guangzhou, China
Third affiliated hospital of southern medical university
🇨🇳Guangzhou, China
shanghai Changzheng hospital, Naval Military Medical University
🇨🇳Shanghai, China
Shenyang general hospital of military region
🇨🇳Shenyang, China
Beijing Jishuitan hospital
🇨🇳Beijing, China