Effect of Brain Blood Flow on Cognition Across Healthy Adulthood

Not Applicable

Completed

• Conditions: Aging; Cognitive decline; Neurological - Studies of the normal brain and nervous system; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12618001603202
• Lead Sponsor: Jim Cotter

Brief Summary

At baseline, older adults had lower cognitive performance and CBF, but similar cerebrovascular reactivity to CO2 and dynamic cerebral autoregulation compared to young adults. In both young and older adults, cognitive performance on a mental switching task was slightly (7%) reduced after indomethacin, but not significantly associated with reductions in CBF (~31%). These results indicate that cognitive performance is broadly resilient against a ~31% reduction in CBF per se in healthy young and older adults.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-09-27
• Study Completion: 2019-02-04
• Last Update Posted: 28 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

No signs of cognitive impairment and non-smoker.

Exclusion Criteria

Currently taking, or required to take any medication listed below:
oCardiac glycosides
oAminoglycosides
oDiuretics
oAnticoagulants
oAntihypertensive
oAspirin
oNon-steroidal anti-inflammatories
oCorticosteroids
Known cardiovascular, cerebrovascular, neurological, metabolic, respiratory, renal, or haematological disease or condition.
Allergic to NSAIDs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified