Effects of Combined Resistance and Endurance Training in Pediatric Cancer Patients During Intensive Treatment Phase

Johannes Gutenberg University Mainz1 site in 1 country35 target enrollmentNovember 2015

ConditionsPediatric Oncology

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Pediatric Oncology
Sponsor: Johannes Gutenberg University Mainz
Enrollment: 35
Locations: 1
Primary Endpoint: Muscle strength: lower limb
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to determine whether combined endurance and resistance training can improve muscle strength in children and adolescents with cancer during the intensive treatment phase.

Registry

clinicaltrials.gov

Start Date

November 2015

End Date

September 2018

Last Updated

7 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Johannes Gutenberg University Mainz

Responsible Party

Principal Investigator

Univ.Prof.Dr.med. Joerg Faber

Univ.-Prof. Dr. med.

Johannes Gutenberg University Mainz

Eligibility Criteria

Inclusion Criteria

•Malignant Tumor
•Medical Treatment in the Center for Pediatrics, Hematology, Oncology and Hemostaseology Mainz (Germany)
•\> 3 years
•Signed Informed Consent

Exclusion Criteria

•Functional and/or cognitive limitations which limit performance during training
•Orthopedic condition which hinders to adequately participate in exercise training
•Heart failure (NYHA III-IV)
•Partial or global respiratory failure
•Symptomatic coronary disease
•Serious therapy-refractory hypertonia
•Sustainable thrombocytopenia \<10.000/µl, f. ex. therapy-refractory autoimmune thrombocytopenia
•Hereditary or acquired thrombocytopenia or coagulation disturbance
•Uncontrolled cerebral spasm
•CNS metastases

Outcomes

Primary Outcomes

Muscle strength: lower limb

Time Frame: Six weeks (pre-post intervention)

Lower limb muscle strength measured by the load (kg) sustained in one repetition maximum test

Secondary Outcomes

Six-minute-walk performance(Six weeks (pre-post intervention))
Muscle strength: upper limb(Six weeks (pre-post intervention))
Body composition(Six weeks (pre-post intervention))
Fatigue(six weeks (pre-post intervention))
Biomarker in Blood(At the beginning of the intervention and three and six weeks after the beginning. Comparing the two time points inbetween study groups)
Quality of Life(Six weeks (pre-post intervention))
Cardiorespiratory performance(Six weeks (pre-post intervention))