Pulmonary Embolism After Liver Resection

• Conditions: Liver Disease; Pulmonary Embolism; Thrombophilia; Death
• Interventions: Procedure: Liver resection; Radiation: Computed Tomography

• Registration Number: NCT01486511
• Lead Sponsor: Beaujon Hospital

Brief Summary

Major surgery is associated with a postoperative hypercoagulable state related to the surgical trauma that may lead to thromboembolic complications. To the investigators knowledge, only two series have reported the risk of PE after liver surgery with an incidence of up to 6.3% The purpose of this study is to identify the independent risk factors associated with the development of PE after elective liver surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Status Verified: 2011-12
• Study First Submitted: 2011-12-04
• Study First Submitted QC: 2011-12-05
• Last Update Submitted: 2011-12-05
• Study First Posted: 2011-12-06
• Last Update Posted: 2011-12-06
• Primary Completion: 2012-01
• Study Completion: 2012-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Age >18 years
• Malignant liver diseases
• Benign liver diseases

Exclusion Criteria

• Age <18 years
• Previous history of thromboembolic events
• Living Donor hepatectomies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Liver resection patients	Liver resection	All patients that underwent elective liver resection for both malignant and benign diseases.
Liver resection patients	Computed Tomography	All patients that underwent elective liver resection for both malignant and benign diseases.

Primary Outcome Measures

Name	Time	Method
Pulmonary embolism	up to January 2012	Blood clots in the lungs that may lead to sudden death.

Secondary Outcome Measures

Name	Time	Method
Complications	up to January 2012	Any type of post-operative complications graded according to the Clavien-Dindo Classification of Surgical Complications
Length of hospital stay	up to January 2012	The duration of hospitalization in days.
Mortality	up to January 2012	Post-operative 90-Day Mortality

Trial Locations

Locations (1)

Prof. Jacques Belghiti; 🇫🇷 Paris, Clichy, France