Magnesium Sulphate reduces the requirement of anaesthetic agents assessed using BIS analysis.
Not Applicable
Completed
- Conditions
- Health Condition 1: H65-H75- Diseases of middle ear and mastoid
- Registration Number
- CTRI/2019/11/021951
- Lead Sponsor
- Medical College and SSGHospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Patients posted for elective tympanomastoidectomy under general anaesthesia requiring endotracheal intubation (surgery duration of 2-3 hours)
Weight : 50 to 70 kg
ASA I & II
Patient willing to participate in the study
Exclusion Criteria
Patients with systemic diseases like respiratory, cardiovascular, hepatic, renal dysfunction, epilepsy, neurological and neuromuscular disorders,
Anticipated difficult airway,
Postural hypotension,
patients on sedatives, psychiatric medications
patients with altered mental status
H/o allergy to egg protein and drugs
Pregnancy and lactating mother
Patient’s unwillingness for participation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To see the requirement of anaesthetic agents intraoperatively– <br/ ><br>-Propofol <br/ ><br>-Vecuronium <br/ ><br>-Sevoflurane. <br/ ><br>Timepoint: For Propofol - following induction of anaesthesia. <br/ ><br>For Vecuronium - following induction and during maintenance of anaesthesia. <br/ ><br>For Sevoflurane - During maintenance of anaesthesia.
- Secondary Outcome Measures
Name Time Method Complications, if any.Timepoint: Intraoperatively <br/ ><br>Postoperatively upto 24 hours;Hemodynamic parameters like HR, BP, SpO2, RR and ECGTimepoint: Baseline <br/ ><br>After adjuvant infusion <br/ ><br>After induction <br/ ><br>Following intubation <br/ ><br>3 min <br/ ><br>5 min <br/ ><br>7 min <br/ ><br>Every 10 min <br/ ><br>Before reversal <br/ ><br>Before extubation <br/ ><br>10 min after extubation <br/ ><br>postoperatively every hourly upto 8 hours. <br/ ><br>;Post operative analgesiaTimepoint: To Note Visual Analogue Scale score at postoperatively 0,2,4,6,8,12,18,24 hour.;Sedation score using Ramsay Sedation ScaleTimepoint: -Before adjuvant infusion <br/ ><br>-5 min after infusion <br/ ><br>-30 min post op <br/ ><br>