Is Pre-operative Infusion of 5% Dextrose Effective in Reducing the Incidence of PONV in Middle Ear Surgery? A Blinded Randomized Control Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- PONV
研究概览
简要总结
With this study, we aim to compare the efficacy of pre-operative dextrose-containing fluid infusion with other fluid for the prevention of PONV in middle ear surgeries.
详细描述
We hypothesized that maintenance of stable level of blood glucose in addition to adequate hydration through preoperative intravenous dextrose 5% infusion will have a rule in decreasing the incidence and severity of PONV; as it reduces insulin resistance and decreases gastric acid secretion; which may contribute to PONV.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA physical status I and ll.
- •Patients undergoing middle ear surgeries, mastoidectomy, or tympanoplasty
排除标准
- •history of dependence or use of antiemetics
- •history of motion sickness
- •presence of psychiatric illness
- •pregnant and lactating women
- •cardiovascular disorders (Ischemic heart diseases, congestive heart failure and valvular diseases)
- •Diabetic patients
研究组 & 干预措施
Control group
Patients will be fasted and not receiving any pre-operative fluids
Dextrose group
Patients will take 100ml/HR of clear fluids (apple juice) during the fasting hours till 2 hrs before the operation and will receive dextrose 5% infusion at a rate of 1ml/kg/h 2hrs before the operation and till the end of the operation
干预措施: Dextrose 5%, normal saline (Dietary Supplement)
Normal saline group
Patients will take 100ml/HR of water during the fasting hours till 2 hrs before the operation and will receive normal saline 0.9% at a rate of 1ml/kg/h (group NS) intravenously (IV)2hrs before the operation and till the end of the operation
干预措施: Dextrose 5%, normal saline (Dietary Supplement)
结局指标
主要结局
PONV
时间窗: 24 hours
incidence
次要结局
未报告次要终点
研究者
Shymaa Fathy
Assistant professor of anesthesia and SICU
Cairo University