ltrasound evaluation of parasternal intercostal muscle and diaphragm in patients with stable chronic obstructive pulmonary disease

Completed

• Conditions: stable chronic obstructive pulmonary disease; chronic obstructive pulmonary disease; diaphragm; parasternal muscle; ultrasound

• Registration Number: TCTR20210402001
• Lead Sponsor: Faculty of Medicine Siriraj Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-02
• Study Completion: 2023-02-28
• Results First Posted: 2024-02-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

COPD group
1. Age >/= 40 years
2. Diagnosed COPD according to GOLD criteria (post-bronchodilator FEV1/FVC < 0.70)
3. Post-bronchodilator FEV1 35-79 %predicted within the past 6 months
Control group
1. Age >/= 40 years
2. Normal spirometry (FEV1/FVC >/= 0.70 and FVC >/= 80 %predicted)

Exclusion Criteria

COPD group
1. History of acute exacerbation of COPD within the past 3 months
2. History of thoracic surgery
3. Diagnosed diaphragm paralysis or chronic neuromuscular disease
4. Pregnant woman
5. Refuse to participate
Control group
1. History of thoracic surgery
2. Other respiratory diseases such as pneumothorax, pleural effusion, or pulmonary fibrosis
3. Pregnant woman
4. Refuse to participate

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thickness of parasternal muscle 5 minutes Ultrasound

Secondary Outcome Measures

Name	Time	Method
Thickening fraction of parasternal muscle 5 mntues Ultrasound,Thickening fraction of diaphragm 5 minutes Ultrasound,Correlation between thickening fraction of parasternal muscle and diaphragm with severity of COPD 5 minutes Ultrasound