Modulation of Cytokines Expression induced by Lactobacillus spp. as a Potential Therapeutic Strategy to Suppress Inflammation Process of Knee Osteoarthritis

Not Applicable

Recruiting

• Conditions: osteoarthritis; bacterial DNA; Inflammatory cytokines

• Registration Number: TCTR20190823002
• Lead Sponsor: Ratchadapisek Sompoch Endowment Fund, Faculty of Medicine, Chulalongkorn university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-23
• Study Completion: 2020-07-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

Patients with knee osteoarthritis by criteria of diagnosis according to American College of Rheumatology who has undergone total knee arthoplasty at King Chulalongkorn Memorial Hospital.

Exclusion Criteria

- Patients with other coexisting arthropathies such as gout, pseudogout, rheumatoid arthritis, SLE, hemochromatosi
- Patients with other coexisting arthritic conditions such as previous knee injury, and previous joint infection
- Patients with other coexisting underlying disease such as cancer, systemic inflammatory conditions, and autoimmune disorders

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cytokine levels after treatment at 6,12,24,72 hourss after end of the intervention Cytometric bead array

Secondary Outcome Measures

Name	Time	Method
Cytokine levels before treatment at 6,12,24,72 hourss after end of the intervention Cytometric bead array