Cytokines in women with recurrent pregnancy loss
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Women with recurrent pregnancy loss
- Registration Number
- CTRI/2010/091/000373
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 360
Inclusion Criteria
1. Age group 18-35 years.
2. Women with history of at least three first trimester pregnancy loss and no history of successful pregnancy.
3. Women enrolled in first trimester preferably at 4-6 weeks of gestation. The pregnancy confirmation is done by estimating serum levels of beta hCG.
Exclusion Criteria
1. Women with 1 or 2 spontaneous abortions.
2. Women with known cause of RPL evaluated as per hospital protocol (anatomical, hormonal, chromosomal, autoimmune or infection).
3. Women who have taken Inj. hCG, proluton etc. during index pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a) To observe the cytokine levels of women with history of RPL and healthy pregnant control at the time of enrollment and the end of study and to compare the variation in their levels. <br/ ><br>b)To observe whether the administration of dydrogesterone causes any change in titers of Th1 (IFN-gamma, TNF-α) and Th2 (IL-4, IL-10) cytokines.Timepoint: Three years
- Secondary Outcome Measures
Name Time Method Secondary outcome:- To find out how many pregnancies continued beyond 20 weeks of gestation and their pregnancy outcome and its correlation with cytokine levels and dydrogesterone administration.Timepoint: Three Years