Analysis of Microplastics in Pediatric Inflammatory Bowel Disease Using Raman Spectroscopy: A Multi-Matrix Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Presence and concentration of microplastics in intestinal tissue samples
研究概览
简要总结
The goal of this observational study is to measure and compare the presence of microplastics in children with inflammatory bowel disease (IBD) and children without IBD. The main questions it aims to answer are:
Are microplastics detectable in different biological samples from children? Are there differences in microplastic burden between children with and without IBD?
Researchers will collect biological samples including: intestinal tissue (from routine endoscopy), stool, urine, blood.
Raman spectroscopy will be used to detect and characterize microplastics in each sample type. Participants will not receive any medication or intervention as part of this study. All samples will be collected during standard clinical procedures.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age <18 years
- •Undergoing clinically indicated gastrointestinal endoscopy
- •For IBD group: confirmed diagnosis of Crohn's disease or ulcerative colitis
- •For control group: no current or past diagnosis of IBD
排除标准
- •Age 18 years or older
- •Lack of informed consent from legal guardian
- •Lack of written assent from the participant if age ≥13 years
结局指标
主要结局
Presence and concentration of microplastics in intestinal tissue samples
时间窗: Day of endoscopy (Baseline)
Quantification of microplastics (number of particles per gram of tissue) detected using Raman spectroscopy in intestinal mucosal biopsies collected during clinically indicated endoscopy.
次要结局
- Comparison of microplastic burden between children with IBD and controls(Baseline (Day of sample collection))