Modification of cerebral and peripheral parameters in energy metabolism by reduction of oxidative processes.
- Conditions
- Healthy Subjects
- Registration Number
- DRKS00010441
- Lead Sponsor
- Sektion für PsychoneurobiologieUniversität zu Lübeck
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 30
Group 1: normal weight; Body mass index 19-25 kg / sqm
Group 2: obesity; Body mass index over 30 kg / sqm
acute / chronic internal medicine, neurological or psychiatric disorders, alcohol or nicotine (> 5 cigarettes / d), medication, competitive sports (eg. marathon runners) and situations of particular pressure of psychological and physical nature (+ general exclusion criteria for MRI examinations: metal implants, pacemakers, artificial joints or heart valves, surgical clips, bone screws or plates, pivot teeth, piercing, large colored tattoos, gunshot wounds, severe claustrophobia).
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The study examine the vitamin C induced changes of cerebral high-energy phosphates adenosine triphosphate (ATP) and phosphocreatine (PCr) by 31-phosphorus magnetic resonance spectroscopy in magnetic resonance imaging (3.0 Tesla). Therefore, baseline spectra and 5 further spectra were recorded on the first and at the last day of the trial in each condition.
- Secondary Outcome Measures
Name Time Method aboratory analysis included peripheral glucose glucose, C-peptide and insulin, as well as the stress parameter ACTH and cortisol before and are exposed after the intervention on day one and eight in both groups.<br>In addition, the vitamin C-mediated change in food intake is examined via a standardized ad libitum breakfast on every first and last day of the experiment.
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