Screen CardRen - A Cross-sectional Observational Cohort Study

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 400

Inclusion Criteria

Inclusion Criteria: Chronic Kidney Disease, stages G1-G4, AND - Estimated glomerular filtration rate (eGFR) as determined by the 2009 CKD-EPI Cr equation = 60 ml/min/1.73m², if UACR =30 mg/g (=3 mg/mmol) OR - eGFR according to CKD-EPI 2009 Cr equation < 60 ml/min/1.73m², but > 15 ml/min/1.73m² Diabetes mellitus type 2 OR - Pathological findings in oral glucose tolerance test (= 200 mg/dl (2h)) OR - documented HbA1c = 6.5 % OR - Intake of any antidiabetic medication (in case of previously established diagnosis of Diabetes mellitus type 2) OR - Fasting blood glucose = 126 mg/dl Arterial Hypertension Grade = 1 OR - Blood pressure of = 140/90 mmHg, defined according to the 2018 ESC guidelines on arterial hypertension (Williams) OR - Intake of antihypertensive drugs Hypercholesterolemia OR - LDL-cholesterol > 130mg/dl OR - Intake of a lipid-lowering medication initiated to treat dyslipoptroteinemia Exclusion Criteria: History of acute kidney injury > stage 1 according to KDIGO criteria in the two weeks prior to study visit - Chronic kidney disease Stage 5 (end-stage renal disease) - Previous diagnosis of chronic heart failure - Acute myocardial infarction in the past 30 days prior to study visit - Stroke in the past 30 days prior to study visit - Known congenital heart disease - Previous diagnosis of a specific cardiomyopathy, infiltrative cardiac disease, pericardial constriction, sarcoidosis, amyloidosis and other storage diseases - Implanted cardiac devices, such as pacemakers, implantable cardioverter-defibrillators, cardiac resynchronization devices - Implanted mechanical valve prosthesis - Inability to give informed consent - Lack of health insurance - Organ transplanted - Intake of immunosuppressive medication - Major surgery in the 6 months before study visit, such as cardiac bypass surgery or valve replacement surgery (thoracotomy), major vascular surgery (such as replacement of aortic root, ascending part, aortic arch or any part of the abdominal aorta), major abdominal surgery (e.g. Whipple procedure, colorectal resection, gastrectomy and others) or limb amputation

Exclusion Criteria

Not provided

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalence of significant asymptomatic cardiac structural abnormalities and cardiac dysfunction;Proteomic analysis

Secondary Outcome Measures

Name	Time	Method
Duration of echocardiographic examination;Time saved by portable echocardiography and automated image analysis;Image quality of cart-based vs. portable echo images