Metabolic Response of Sedentary Participants to a Long-term Exercise Intervention
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Change in TEE.
研究概览
简要总结
The goal of this clinical trial is to study the effectiveness of aerobic exercise in treating obesity in adults and to assess the efficacy of exercise. The primary research questions it seeks to address are as follows:
- To what extent does exercise increase the total energy expenditure of participants?
- Why and how does the energy expenditure from exercise not fully compensate for the total energy expenditure (TEE)?
- Researchers will assess the efficacy and potential challenges of using exercise as a treatment for obesity by comparing the measurement data before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
Participants will engage in the following activities:
- Engage in running sessions supervised five times a week for a duration of 12 weeks.
- Attend laboratory sessions both before and after the exercise intervention period for metabolic and anthropometric measurements, as well as sample collection.
- Return to the laboratory for further metabolic and anthropometric measurements and sample collection8 weeks post-completion of exercise intervention.
详细描述
Based on previous research findings, scientists found that exercise results in energy compensation. In a non-interventional setting, energy intake and expenditure undergo a dynamic equilibrium process. Nonetheless, the energy deficit induced by exercise is offset by other physiological or psychological behaviors, leading to a diminished energy discrepancy caused by exercise, thereby mitigating the weight loss effects typically associated with exercise(Pontzer et al 2016: Current Biology).Controlled dietary experiments have indicated that long-term exercise results in approximately 22% energy compensation (Bouchard et al 1994: Obesity Research); however, the underlying source and mechanism of this compensation remains ambiguous. Analyses of Total Energy Expenditure (TEE) in 1754 individuals have demonstrated that the energy compensation from exercise primarily emanates from a reduction in Basal Energy Expenditure (BEE), with only an average of 72% of the energy expended during exercise being utilized for additional energy expenditure (Careau et al 2021: Current Biology). Nevertheless, this deduction is restricted by the measurements of energy intake, Adaptive thermogenesis, Thermic Effect of Food (TEF), and Activity-related Energy Expenditure (AEE), emphasizing the necessity of exercise intervention studies to comprehensively grasp the pathways and mechanisms of energy compensation.
To tackle the challenges posed by overweight and obesity, enhance residents' quality of life, and delve deeper into the intricacies of energy compensation, this research project focuses on examining the metabolic reactions of the body to exercise interventions. Through the analysis of pre- and post-exercise energy expenditure and intake, body composition, metabolism, microbiota, and metabolomics alterations in humans, the primary goal is to thoroughly elucidate the principal factors and mechanisms behind energy compensation. This clinical trial consists of four phases: pre-exercise intervention baseline measurement, exercise intervention, Immediately after 12 weeks' exercise intervention measurement, and follow-up measurement 8 weeks post-completion of the exercise intervention.
Pre-exercise intervention baseline measurement:
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Anthropometric measurements: body weight, height, and body composition
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Body weight: At visit 1, fasting body weight will be measured using a calibrated seca at the beginning of the visit. Fasting weight will be measured at visit 2 and, if applicable.
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Height: Height (to +0.1 cm) will be measured by seca 217 stable without wearing shoes.
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Body composition:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sedentary individuals
- •BMI ≥ 18.5 kg/m2
排除标准
- •Individuals who have undergone major surgery in the past 6 months (excluding tooth extraction);
- •Individuals on long-term medication;
- •Individuals with metabolic and cardiovascular diseases such as diabetes, hypoglycemia, and hypertension;
- •Individuals with exercise-related injuries, including joint diseases and fractures;
- •Individuals diagnosed with infectious diseases such as HIV, tuberculosis, malaria, etc.;
- •Individuals with mental and neurological disorders including anorexia nervosa;
- •Individuals who have attempted weight loss or gain through various methods in the past three months;
- •Individuals in preconception, pregnancy, and lactation periods;
- •Individuals with autism and those with metal implants in their bodies.
研究组 & 干预措施
Exercise intervention
Participants will run on treadmill under the supervision of the researcher
- Intensity:60% of VO2max
- Duration: for 12 weeks
- Frequency: 5 times a week.
干预措施: Exercise intervention (Behavioral)
结局指标
主要结局
Change in TEE.
时间窗: Three times, it takes 14 days for each time: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
The change in TEE will be evaluated using the DLW method before and after exercise intervention.
Change in TEF and REE.
时间窗: Three times, it takes 1 days for each time: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
The change in BEE and TEF will be measured through indirect calorimetry in a respiratory chamber.
Change in exercise energy expenditure.
时间窗: Three times, it takes 14 days for each time: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
The change in exercise energy expenditure will be assessed using indirect calorimetry with a respiratory hood system (COSMED).
Change in food intake.
时间窗: Three times, food intake assessment takes 2 days: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
Food intake will be assessed using a 2-day food record complemented by photographing and weighing the food before and after consumption.
Change in physical activity.
时间窗: Three times, it takes takes 14 days: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).
The physical activity levels of the participants will be monitored through the use of a GT3X accelerometer.
次要结局
- Change in fasting glucose and postprandial glucose.(Three times, 7 days per each time: before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).)
- Change in circulating hormones and metabolites.(8 times, 1 minutes for each collection, 7 days for analysis. Every months (week0, 4, 8,12, and 30), and after exercise energy expenditure test(week 0,12, and 20)))
- Change in intestinal microbiota.(Three times, it takes 5 minutes for collection, 7 days for analysis. before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).)
- Change in fat mass.(Three times, it takes 10 minutes, before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).)
- Change in fat free mass.(Three times, it takes 2 minutes for each time, before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).)
- Change in bone mass.(Three times, it takes 7 minutes for each time, before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).)
研究者
John R. Speakman
Professor
Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences