comparison of vasopressin and phenylephrine in reducing blood loss during laparoscopic myomectomy

Not Applicable

Conditions: Health Condition 1: O- Medical and Surgical

Registration Number: CTRI/2023/10/058875

Lead Sponsor: All india institute of medical sciences Patna

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1.Age between 15-49 years.

2.BMI between 18-29.9.

3.1-5 symptomatic intramural myomas

4.Presenting with abnormal uterine bleeding, pelvic pressure or pain, infertility or recurrent miscarriage and are candidates for abdominal myomectomy.

5.Largest uterine fibroid size of <10 cm

6.not pregnant at the time of presentation (i.e. negative urine pregnancy test or last menstrual period within the last 4 weeks);

7.appropriate medical status for laparoscopic surgery (American Society of Anesthesiologists Physical Status Classification 1 or 2).

Exclusion Criteria

1.History of previous abdominal or pelvic surgery except Cesarian section.

2.History of pelvic or ovarian endometriosis or abdominal tuberculosis.

3.Patient with subserous or submucosal fibroid or adenomyoma.

4.Patients who are not candidate for laparoscopic myomectomy.

5.any pelvic abnormalities requiring concomitant surgery

6.myoma with a maximal diameter of 10 cm based on pre-operative ultrasound

7.Allergy to phenylephrine and vasopressin

8.Hypertension, Diabetes Mellitus, Cardiac and pulmonary diseases. (ASA >2)

9.Obesity BMI > 30 kg/m².

10.Anemia Hb < 10 g/dL.

11.Bleeding disorder or use of anticoagulation.

12.Preoperative use of hormonal therapy as GnRH analogues or oral contraceptive pills or mifepristone or ulipristal acetate within 3 months preceding surgery.

13.more than five myomas

14.conversion to open surgery

15.need for adhesiolysis

16.Pregnancy.

17.Postmenopausal.

18.Not giving written informed consent.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intraoperative blood loss estimated by calculating the sum of canisters containing irrigation fluids and suctioned (ml)blood minus used irrigation solutionTimepoint: baseline, and after completion of surgery, that is skin closure

Secondary Outcome Measures