Wholegrain diet and blood pressure study: the WISH study

Not Applicable

Recruiting

• Conditions: Pre-hypertension; Circulatory System

• Registration Number: ISRCTN17517647
• Lead Sponsor: niversity of Aberdeen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-11-24
• Last Update Posted: 4 March 2019
• Study Completion: 2020-09-01

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

1. Men and women
2. Aged 30-65 years
3. Body mass index (BMI) between 18.5 and 35kg/m2
4. 135mmHg

Exclusion Criteria

1. 160 mm Hg 2. Individuals with CVD, diabetes or fasting blood glucose concentration > 7.0mmol/L, asthma, or thyroid conditions
3. Subjects with eating disorders, high habitual intake of wholegrain food (> 7 portions per weeks) or taking regular medication or supplements known to affect any dependant variable measured
4. Pregnant women
5. Individuals with bowel disorders (Crohn’s, IBS, coeliac)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure is measured using blood pressure cuffs and 24hr ABPM at six weeks follow up.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Arterial stiffness (Aix) and central aortic pressure is measured using Sphygomocor at six weeks follow up<br> 2. Diastolic blood pressure is measured using blood pressure cuffs and 24hr ABPM at six weeks follow up<br> 3. Aldosterone and angiotensin concentration in plasma measured using blood tests at six weeks follow up<br> 4. Kidney function is determined using estimated glomerular filtration rate (eGFR) based on serum creatinine concentration at six weeks follow up<br>