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入排标准

•1 )Patient with acute and chronic anal fissure. 2) Patient without previous history of peri-anal fistula. 3) Patient without previous history of peri-anal abscess. 4) Patient without previous history of IBD, radiation, STD, TB Chemotherapy. 5) Patient without previous history of hemorrhoidectomy or peri-anal procedure. 6) Patient without previous history of migraine. 7) Patient without previous history of no pregnant. 8) Patient without previous history of anterior or posterior midline fistula. 9) Patient without previous history of IHD.

Randomized Double-blind Placebo Controlled Trial of Topical Platelet Lysate hydrogel in patients with anal fissure referee to colorectal research center of shiraz medical university of medical sciences.

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