Measuring and investigating causes of fluid accumulation in tissues and in critically unwell children in intensive care

Not Applicable

• Conditions: Fluid overload; Oedema; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system

• Registration Number: ACTRN12621000558820
• Lead Sponsor: The Royal Children's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-12
• Last Update Posted: 5 July 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1.Mechanically ventilated at enrolment or expected to be intubated upon elective PICU admission
2.Admitted to the PICU within previous 72 hours
3.Expected to be mechanically ventilated until the day after tomorrow
4.Expected to have arterial or venous access for 48 hours after enrolment
5.Can be safely and accurately weighed

Exclusion Criteria

1.Unable to be weighed safely (haemodynamic instability, traumatic brain injury and unstable intracranial pressure, unsecured spinal injury, severe orthopaedic injuries, insecure endotracheal tube)
2.Children expected to stay in PICU less than 48 hours
3.Cerebral venous obstruction/proximal upper limb, upper leg venous obstruction or thrombosis/ cavo- pulmonary shunt
4.Ocular/facial injury/Surgery
5.Inability to lie supine in a fixed position
6.Prone positioning in the 6 hours prior to enrolment
7.Known protein losing states – e.g. Nephrotic syndrome, protein losing enteropathy, lymphangiectasia
8.Prior enrolment in the same study
9.Expected weight > 65 kg
10.COVID-19 positive or clinical suspicion of COVID-19

Study & Design

• Study Type: Observational
• Study Design: Not specified