Early Intervention for amnestic Mild Cognitive Impairment: A Randomised Trial of Memory Management

Phase 2

Completed

• Conditions: Mild Cognitive Impairment; Neurological - Other neurological disorders

• Registration Number: ACTRN12605000711617
• Lead Sponsor: a Trobe University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-11-04
• Study Completion: 2012-02-20
• Last Update Posted: 3 March 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 219

Inclusion Criteria

The sample will consist of families who have a family member reporting memory complaint and recently assessed within a Cognitive, Dementia & Memory Service (CDAMS or memory clinic) and also healthy older adult volunteers recruited from the local community via advertising. Patients are referred to the Cognitive Dementia & Memory Service for an evaluation of suspected dementia and will be assigned to the potential pool of participants if they receive a diagnosis of mild cognitive impairment after a comprehensive clinical assessment. MCI can describe a range of presentations with mild neuropsychological difficulties, but for this study the focus will be on amnestic MCI.Inclusion/exclusion criteria: (i) Participant presents with memory complaint; (ii)Objective memory impairment on neuropsychological tests; (iii) Normal general cognitive function; (iv) Adequate activities of daily living; (v) Fails to reach criterion for clinical dementia according to NINCDS-ADRDA guidelines.Additional selection criteria: (i) English speaker; (ii) Living in the community.

Exclusion Criteria

Diagnosis of dementia; co-morbid medical conditions associated with functional decline or impact on cognition; untreated major depression and any other severe psychiatric disorder and /or behavioural problems; significant impairment of vision or hearing or communication that would interfere with study participation; availability during the study period.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the efficacy of the intervention, outcome wil be assessed by performance on neuropsychological tests of memory impairment and disability in everyday memory; self-report of everyday memory ability; knowledge and self-report of use of memory strategies in everyday life by the participant and family participant.[Assessments, for both groups, will be undertaken at pre-intervention (baseline), post-intervention, and at 6-month follow-up.]

Secondary Outcome Measures

Name	Time	Method
Psychological well-being: self-report and family report[Undertaken at pre-intervention (baseline), post-intervention, and at 6-month follow-up and these will be used to predict individual response to intervention.]