Comparison of plasma volume, extracellular water and body weight following restricted or standard intraoperative fluid management in patients undergoing elective gastrointestinal surgery

Not Applicable

Recruiting

• Conditions: Not Applicable

• Registration Number: KCT0002683
• Lead Sponsor: Asan Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Patients undergoing elective colorectal or stomach surgery under open laparotomy
2. Age = 19 years
3. American Society of Anesthesiologists (ASA) physical status 1 or 2

Exclusion Criteria

1. Laparoscopic surgery
2. Arrhythmia (except sinus bradycardia and tachycardia)
3. Ischemic heart disease
4. Chronic obstructive pulmonary disease (COPD)
5. Ascites determined by abdominal computed tomography
6. Pretibial pitting edema
7. Hypoalbuminemia (< 2.5 g/dL) or hypoproteinemia (< 5.5 g/dL)
8. Estimated glomerular filtration rate < 60 ml/min
9. Aspartate aminotransferase/alanine aminotransferase (AST/ALT) > 100 IU/L
10. Blood urea nitrogen (BUN) > 30 mg/dl
11. Serum creatinine > 2.0 mg/dl
12. Prothrombin time (PT) > 1.5 international normalized ratio (INR)
13. Activated partial thromboplastin time (aPTT) > 40 sec
14. Hemoglobin < 10 g/dl
15. Hematocrit < 30%
16. Platelet count < 100 × 103 /µL
17. Body weight < 40 or > 100 kg
18. Systemic exposure to indocyanine green (ICG) within 24 h prior to surgery
19. History of allergy to iodides

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
plasma volume

Secondary Outcome Measures

Name	Time	Method
Intraoperative net fluid;Hemodynamic variables;Extracellular water volume;Body weight