Identification of Markers (Klotho-FGF23 Axis) as Determinant in the Evolution of Arterial Stiffness During the First Year of Renal Transplant
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Hopital Foch
- 入组人数
- 117
- 试验地点
- 4
- 主要终点
- Carotid-femoral pulse wave velocity
研究概览
简要总结
The primary objective is to show that the contribution of Klotho by the renal graft is an independent determinant of the evolution of the recipient's central arterial stiffness during the first year of renal transplant. The contribution of Klotho by the graft will be estimated by: its circulating concentrations assay, its urinary excretion assay, and, indirectly, by the circulating concentrations of FGF23. The recipient's central arterial stiffness will be estimated by the measure of the carotid-femoral pulse wave velocity, noninvasive reference method for measuring aortic stiffness in human.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Man or woman 18 to 70 years old
- •Renal transplant
- •Dead donor or alive donor
- •Immunosuppression including a calcineurin inhibitor
- •Written consent
排除标准
- •MultipleTransplant
- •Morbid Obesity (Body Mass Index (BMI)> 40 kg/m2 sc)
- •Cardiac Arrhythmia
- •Lower limbs occlusive arterial disease
- •Impossibility to understand the information form
研究组 & 干预措施
Renal Transplant
干预措施: Non invasive Arterial investigations (Procedure)
Renal Transplant
干预措施: Biological sample (Biological)
Renal Transplant
干预措施: Abdominal tomodensitometry (Procedure)
结局指标
主要结局
Carotid-femoral pulse wave velocity
时间窗: 12 months
次要结局
- Sectional carotid stiffness(12 months)
- Carotid intima-media thickness(12 months)
- Endothelial function(12 months)
- Arterial calcification(12 months)
- Pulsed central veinous pressure(12 months)
- Klotho concentration(1 day)
- FGF23 concentration(1 day)