Memory and Picture Viewing Study

Completed

• Conditions: Brain Reactivity of Non-smokers Undergoing fMRI Scanning; Healthy

• Registration Number: NCT00736203
• Lead Sponsor: Duke University

Brief Summary

The purpose of this study is to obtain a database of brain function from a sample of non-smokers while they do tasks in an MRI (magnetic resonance imaging) machine. Our hypothesis is that among nonsmokers, reactivity to smoking cues will be highly similar to control cues but may vary as a function of attitudes toward smoking and/or family history of smoking. We also hypothesize that brain activity during the n-back task will be more similar to data collected during this task when smokers are not abstinent.

Detailed Description

Thirty six non-smokers will undergo functional magnetic resonance imaging (fMRI) scanning. During scanning participants will complete the n-back task-a measure of working memory-and the cue-reactivity task-a measure of responses to smoking cues. Before scanning, participants will complete a training session where they will be familiarized with the tasks.

All participants will have to pass a screening visit in order to be included in the study.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2008-07
• Study First Submitted: 2008-08-13
• Study First Submitted QC: 2008-08-14
• Study First Posted: 2008-08-15
• Primary Completion: 2011-11
• Study Completion: 2011-11
• Status Verified: 2013-01
• Last Update Submitted: 2013-02-06
• Last Update Posted: 2013-02-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 116

Inclusion Criteria

• generally healthy
• right-handed non-smokers
• between the ages of 18-55
• an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100 ng/mL or less (to confirm a non-smoker)
• having smoked < 50 cigarettes in their lifetime

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Exclusion Criteria

• inability to attend all sessions
• significant health problems (hypertension, emphysema, seizure disorder, history of significant heart problems)
• use of psychoactive medications
• use of any tobacco or nicotine containing products
• current alcohol or drug abuse
• use of illegal drugs as measure by a urine drug screen
• presence of conditions that would make MRI unsafe (pacemaker, metallic implants

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
brain reactivity	3 weeks

Trial Locations

Locations (1)

Duke University Medical Center; 🇺🇸 Durham, North Carolina, United States