Maca in Healthy Subjects After Strenuous Endurance Exercise
- Conditions
- Healthy
- Interventions
- Dietary Supplement: macaDietary Supplement: placebo
- Registration Number
- NCT05779488
- Lead Sponsor
- Taipei Medical University
- Brief Summary
The aim of this study is to investigate Lepidium meyenii (Maca) extract supplementation on exercise-induced responses of the biochemical, and physiological parameters.
- Detailed Description
Thirty healthy male participants were divided into Maca group (2.25 g of Maca extract, twice per day for 12 weeks) and placebo group (n = 15). All participants conducted a graded exercise test on treadmill to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 70% VO2max was conducted for an exhaustive endurance exercise test by treadmill for 1 hours, followed by 90% VO2max until exhaustion.The time to exhaustion, peak oxygen consumption, maximal heart rate and average heart rate will be recorded during the exercise period. Venous blood samples will be drawn before, immediately after, 2-hour after, 4-hour after, and 24-hour after the exhaustive endurance exercise test. Data was analyzed by Two-way mixed design ANOVA.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Male
- Target Recruitment
- 50
The volunteers included have conditions as stated below :
- male adult whose no history of cardiovascular, liver, kidney and diabetes disease
- no acute sport injury
- did not participated in any clinical trials or research in the last 3 months before our experiment
- no supplements were taken during the experimental period
- were requested to maintain their regular daily life style and avoid alcohol intake
The volunteers were excluded if they have the situation stated below:
- history of cardiovascular, liver, kidney and diabetes disease
- acute sport injury
- participated in any clinical trials or experimental research in the last 3 months before our experiment
- taking supplement during the experimental period
- did not maintain their regular eating habit or drink alcohol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description maca group maca - Placebo group placebo -
- Primary Outcome Measures
Name Time Method Concentration of IL-2 24-hour after exercise Concentration of SOD 24-hour after exercise Concentration of catalase 24-hour after exercise Concentration of leukocyte 24-hour after exercise Concentration of neutrophil 24-hour after exercise Concentration of IFN-γ 24-hour after exercise Concentration of GPx 24-hour after exercise Concentration of CK 24-hour after exercise Concentration of IL-6 24-hour after exercise Concentration of lymphocyte 24-hour after exercise Concentration of CD4+ 24-hour after exercise Concentration of GSSG 24-hour after exercise Concentration of IL-4 24-hour after exercise Concentration of IL-10 24-hour after exercise Concentration of testosterone 24-hour after exercise Concentration of LH 24-hour after exercise Concentration of NO 24-hour after exercise Concentration of GOT 24-hour after exercise Concentration of GPT 24-hour after exercise Concentration of BUN 24-hour after exercise Concentration of TNF-α 24-hour after exercise Concentration of GSH 24-hour after exercise Concentration of CD8+ 24-hour after exercise Concentration of CD19+ 24-hour after exercise Concentration of CK-MB immediately after exercise Concentration of IL-1β 24-hour after exercise Concentration of CD56+ 24-hour after exercise IConcentration of GSSG before exercise Concentration of LDH 24-hour after exercise Concentration of creatinine 24-hour after exercise Concentration of IL-8 24-hour after exercise Concentration of TBARS 24-hour after exercise Concentration of PC 24-hour after exercise Concentration of cTnI 24-hour after exercise Concentration of NT proBNP 24-hour after exercise Concentration of FSH 24-hour after exercise
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Taipei Medical University
🇨🇳Taipei, Taiwan