Tolerance and Potential Synergistic Effect of the Combination of Intranasal Esketamine and Non-selective MAOI
- Conditions
- Depression Anxiety Disorder
- Registration Number
- NCT05530668
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
There are already recently published data on the tolerability and efficacy of the combination of ketamine and/or esketamine with MAOIs. However, these reports are few and far between, and to our knowledge, there are no data involving intranasal esketamine.
Given the numerous interactions between MAOIs and other antidepressants, and the impossibility of combination, this pharmacological class is neglected. This is despite the fact that MAOIs are the only truly tri-aminergic drugs, that they have unparalleled efficacy in certain forms of resistant apathetic depression, and that new, more dietary permissive forms have appeared on the market. The arrival of antidepressants that can be combined with MAOIs, such as ketamine and esketamine, changes the situation and could offer a new treatment opportunity to many patients in a therapeutic impasse. For these opportunities to become a reality, sharing the clinical experience gained by specialized centers is essential.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Not provided
- Subject who has expressed opposition to the reuse of their data for scientific research purposes.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of adverse events for each patient Files analysed retrospectively from January 01, 2018 to March 31, 2022 will be examined
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Service de physiologie - Explorations fonctionnelles - CHU de Strasbourg - France
🇫🇷Strasbourg, France