Transcranial Magnetic Stimulation (TMS) in Patients With Mild Cognitive Impairment (MCI) and Alzheimer Disease (AD): A Twelve-year Retrospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 73
- 主要终点
- Controlled Oral Word Association Test
研究概览
简要总结
The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety and efficacy of TMS.
详细描述
The investigators compiled demographic, clinical, and neurocognitive data on all patients who had received TMS for any reason in the clinic over a 12-year period. Of 236 patients receiving TMS, 59 patients with AD and 14 with MCI satisfied study criteria and were compared to controls from the National Alzheimer's Coordinating Center (NACC). Neurocognitive outcomes were compared between magnetic resonance imaging (MRI) and electroencephalogram (EEG)-grid guided TMS in patients. Tolerability data was reviewed for all patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for possible or probable Alzheimer's disease.
- •Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for mild cognitive impairment.
- •Patients must have undergone at least two standardized neurocognitive batteries before and after beginning TMS.
- •Patients must have received greater than or equal to five (5) TMS sessions in less than one year.
排除标准
- •Patients with dementias from other causes, such as Lewy Body disease.
结局指标
主要结局
Controlled Oral Word Association Test
时间窗: 05/01/2008-05/30/2020
Animal score and percentile
Boston 30-item naming test
时间窗: 05/01/2008-05/30/2020
total correct (with cues)
Wechsler Adult Intelligence Scale III
时间窗: 05/01/2008-05/30/2020
object assembly
Wechsler Memory Scale III
时间窗: 05/01/2008-05/30/2020
Visual delayed memory score and percentile
Buschke Selective Reminding Test, 12 item
时间窗: 05/01/2008-05/30/2020
Total recall score
Rosen Drawing Test
时间窗: 05/01/2008-05/30/2020
Total score
Buschke Selective Reminding Test, 12 item, 15 minute
时间窗: 05/01/2008-05/30/2020
Delayed recall score
Processing speed
时间窗: 05/01/2008-05/30/2020
Total score and percentile
Mini-mental status examination
时间窗: 05/01/2008-05/30/2020
Total score
次要结局
未报告次要终点
研究者
Gayatri Devi, MD
Principal Investigator
The New York Memory Services