Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance, Inflammation, Gene Expression and Epigenetic Signatures
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Loughborough University
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Strength
Study Overview
Brief Summary
The aim of the study is to determine whether fish oil (specifically omega-3 long chain polyunsaturated fatty acids [EPA-DHA]) supplementation can enhance eccentric resistance exercise performance when combined with a resistance exercise training study. The investigators aim to establish the potential mechanisms that might mediate performance changes at a cellular level.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 55 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Resistance exercise training within the past 6 months
- •Vitamin or fish oil supplementation over the past 6 months
- •Habitual use of anti-inflammatory drugs
- •History of heart disease
- •History of coagulation/bleeding disorder
- •History of metabolic disease
- •Serious allergy
- •Known to have blood-borne virus
- •Females (Due to differences in cell membrane incorporation of Omega-3 between the sexes and the testing schedule being unable to fit in with menstrual cycle, altering the blood markers that are being measured)
- •Currently no symptoms of general illness
Arms & Interventions
Placebo
Olive Oil 6g/ day - Premium Omega-3, Norwegian Pure-3, Oslo, Norway
Intervention: Placebo (Dietary Supplement)
Fish Oil
Fish oil 5.1g/ day - Premium Omega-3, Norwegian Pure-3, Oslo, Norway
Intervention: Fish Oil (Dietary Supplement)
Outcomes
Primary Outcomes
Strength
Time Frame: Change from baseline strength at 11 weeks
Quadriceps and Hamstring strength using an isokinetic dynamometer
Leg power
Time Frame: Change from baseline strength at 11 weeks
Dynamic leg power assessed through jump height on force platform
Secondary Outcomes
No secondary outcomes reported
Investigators
Lynsey Wilson
Technical Tutor in Exercise Physiology/ PhD Student
Loughborough University