Relation of abdominal pressure to kidney function

Completed

• Conditions: Critically ill Obstetric patients i.e., those pregnant patients or those within 6 weeks of delivery who require admission to the ICU

• Registration Number: CTRI/2016/11/007422
• Lead Sponsor: University College of Medical Sciences and GTB Hospital

Brief Summary

Intra-abdominal pressure (IAP) of critically ill obstetric patients who are admitted to the ICU will be measured using the intra-vesicle or bladder method, considered as the gold standard technique for measuring IAP. This involves use of an external manometer/ transducer connected to indwelling Foley bladder catheter. Also, the incidence of early Acute Kidney Injury (AKI) (within first 2 days of ICU stay) will be evaluated using the pre-defined criteria with serum creatinine/ urine output. The relation between IAP values and AKI would be sought. Also the role of urinary NGAL (Neutrophil Gelatin Associated Lipocalin) in predicting AKI will be evaluated, for which patient’s urine sample will be collected at the time of ICU admission, centrifuged and stored at -80**°**C for future assay with ELISA kit.

The sequential organ failure assessment (SOFA) severity illness score for the first 2 days of ICU stay, and mortality as well as duration of stay in ICU will also be recorded.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-21
• Study Completion: 2017-03-27
• Last Update Posted: 2017-12-29

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• Obstetric patients admitted to ICU, with 2.
• For causes related directly to pregnancy such as preeclampsia, haemorrhage etc.
• For causes related indirectly to pregnancy such as worsening of diabetes, sepsis etc.
• Needing an indwelling urinary Foley catheter.

Exclusion Criteria

• Patients with an anticipated duration of stay in ICU of <24 hours, 2.
• Those not needing a urinary Foley catheter, 3.
• Or with any contraindication to IAP measurement such as bladder injury or pelvic fracture.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
EARLY AKI (acute kidney injury) (Diagnosed by Urine output and serum Creatinine)	Every 24 hours for first two days of ICU stay

Secondary Outcome Measures

Name	Time	Method
Intra- Abdominal Pressure	Urinary NGAL

Trial Locations

Locations (1)

University College of Medical Sciences and GTB Hospital; 🇮🇳 East, DELHI, India

University College of Medical Sciences and GTB Hospital

🇮🇳East, DELHI, India

Dr Asha Tyagi

Principal investigator

9818606404

drashatyagi@gmail.com