Role of Intra-Abdominal Pressure in Acute Kidney Injury in Critically Ill Obstetric Patients: A Prospective Cohort Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- EARLY AKI (acute kidney injury) (Diagnosed by Urine output and serum Creatinine)
研究概览
简要总结
Intra-abdominal pressure (IAP) of critically ill obstetric patients who are admitted to the ICU will be measured using the intra-vesicle or bladder method, considered as the gold standard technique for measuring IAP. This involves use of an external manometer/ transducer connected to indwelling Foley bladder catheter. Also, the incidence of early Acute Kidney Injury (AKI) (within first 2 days of ICU stay) will be evaluated using the pre-defined criteria with serum creatinine/ urine output. The relation between IAP values and AKI would be sought. Also the role of urinary NGAL (Neutrophil Gelatin Associated Lipocalin) in predicting AKI will be evaluated, for which patient’s urine sample will be collected at the time of ICU admission, centrifuged and stored at -80**°**C for future assay with ELISA kit.
The sequential organ failure assessment (SOFA) severity illness score for the first 2 days of ICU stay, and mortality as well as duration of stay in ICU will also be recorded.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 42.00 Year(s)（—）
- 性别
- Female
入选标准
- •Obstetric patients admitted to ICU, with
- •For causes related directly to pregnancy such as preeclampsia, haemorrhage etc.
- •For causes related indirectly to pregnancy such as worsening of diabetes, sepsis etc.
- •Needing an indwelling urinary Foley catheter.
排除标准
- •Patients with an anticipated duration of stay in ICU of <24 hours,
- •Those not needing a urinary Foley catheter,
- •Or with any contraindication to IAP measurement such as bladder injury or pelvic fracture.
结局指标
主要结局
EARLY AKI (acute kidney injury) (Diagnosed by Urine output and serum Creatinine)
时间窗: Every 24 hours for first two days of ICU stay
次要结局
- Intra- Abdominal Pressure(Urinary NGAL)