Intent of Surgery for IPMN

Recruiting

• Conditions: Intraductal Papillary Mucinous Neoplasm

• Registration Number: NCT07216521
• Lead Sponsor: NYU Langone Health

Brief Summary

This multicenter retrospective observational cohort study seeks to:

1. Classify surgical intent in patients with resected Intraductal Papillary Mucinous Neoplasms (IPMN) and quantify the proportion of IPMN-associated cancers diagnosed as overt pancreatic cancer with incidental IPMN association on pathology.

2. Compare clinicopathologic features and outcomes between surveillance-detected and incidentally detected IPMN-derived pancreatic cancers.

3. Revise and redefine risk features limited to patients undergoing surgery for IPMN-related indications, identifying optimal predictors of malignant IPMN (high-grade dysplasia or invasive cancer).

Detailed Description

Not available

Study Timeline

• Study Start: 2025-09-15
• Status Verified: 2025-10
• Study First Submitted: 2025-10-09
• Study First Submitted QC: 2025-10-09
• Last Update Submitted: 2025-10-09
• Study First Posted: 2025-10-14
• Last Update Posted: 2025-10-14
• Primary Completion: 2025-12
• Study Completion: 2025-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• All patients (18 years old of greater) who underwent surgical resection for IPMN (including low-, high-grade dysplasia, or invasive carcinoma) between July 1, 2015 and July 1, 2025.

Exclusion Criteria

• Patients with concomitant pancreatic ductal adenocarcinoma (PDAC)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Grade of IPMN on Final Pathology	Day 0 (Retrospective Analysis)

Secondary Outcome Measures

Name	Time	Method
Recurrence Free Survival	Day 0 (Retrospective Analysis)	Length of time from surgery for IPMN to recurrence.
Overall Survival	Day 0 (Retrospective Analysis)	Length of time from surgery to death due to any cause.

Trial Locations

Locations (13)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States

Johns Hopkins University; 🇺🇸 Baltimore, Maryland, United States

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States

NYU Langone Health; 🇺🇸 New York, New York, United States

Memorial Sloan Kettering; 🇺🇸 New York, New York, United States

Duke University; 🇺🇸 Durham, North Carolina, United States

MD Anderson Cancer Center; 🇺🇸 Houston, Texas, United States

Nanjing University; 🇨🇳 Nanjing, China

Heidelberg University; 🇩🇪 Heidelberg, Germany

San Raffaele Hospital; 🇮🇹 Milan, Italy

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