Circadian timing system (CTS) characteristics in bipolar disorder: investigation of possible endophenotypes

Completed

Conditions: bipolar disorder
manic depressive disorder
10026753

Registration Number: NL-OMON39203

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 600

Inclusion Criteria

-Patients:
- Bipolar I disorder according to the DSM-IV , with medical record of at least one clinical treatment for mania
-Dutch ancestry
-Age >18 years;Healthy controls:
-Age>18 years
-Dutch ancestry
-IQ >80 ;Family member:
- no bipolar I disorder.

Exclusion Criteria

Patients:
-Age <18 years
-Premorbid IQ <80
-Poor physical health or suffering from severe dementia or other neurodegenerative disease
-Patients under current treatment or detention under the Dutch governmental health act
-Use of anti-coagulants
-Pregnancy;Family members:
-Bipolar I disorder
-Age <18 years
-IQ <80
-Poor physical health or suffering from severe dementia or other neurodegenerative disease
-Use of anti-coagulants
-Pregnancy
Healthy controls:
- Age < 18 years
- IQ < 80
-Use of anti-coagulants
-Poor physical health or suffering from severe dementia or other neurodegenerative disease
-Pregnancy

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Identifying circadian parameters as possible endophenotypes for bipolar<br /><br>disorder. The circadian parameters assessed in this study include rest-activity<br /><br>rhythm parameters (total sleep duration, sleep onset latency, sleep efficiency,<br /><br>interdaily stability and intradaily variability), chronotype and circadian<br /><br>rhythm of gene expression. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Effects of moodstabilizers and other medication on circadian rhythm<br /><br>parameters.<br /><br>- Relationship between mood state at study entry and circadian rest-activity<br /><br>rhythms.</p><br>