Phase advancing the circadian system with short pulses of blue light

Completed

• Conditions: circadian alignment; evening types; late chronotypes

• Registration Number: NL-OMON34171
• Lead Sponsor: Philips Consumer Lifestyle

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 14

Inclusion Criteria

Healthy men and women between ages 20 and 30 y with a median to late sleep phase.

Exclusion Criteria

• Two time zones transmeridian flights (or more) one month prior to participation
• Regularly taking naps (on average more then 2 per week)
• Shift work during the last 3 months
• Colour blindness
• Visually impaired
• Ophthalmologic complaints or a history of eye surgery
• Somatic and psychiatric diseases (depressed mood rating BDI-II-NL >8
• History of chronic diseases
• Excessive daily amount of caffeinated drinks
• Alcohol or drug problems
• Regular medication 3 months prior to participation
• Smokers
• Habitual midsleep later then 6:07 (>5% extreme late chronotype)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter is the rhythm of melatonin concentration in saliva. A<br /><br>shift in phase markers of the melatonin rhythm is interpreted as a shift of the<br /><br>endogenous circadian pacemaker.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>(1) Ambulatory rest-activity rhythms<br /><br>(2) Subjective ratings, e.g. sleepiness, headache, chronotype</p><br>