Prone Fluid Responsiveness in Children

Not Applicable

• Conditions: Pediatric ALL

• Registration Number: NCT05449886
• Lead Sponsor: Seoul National University Hospital

Brief Summary

In pediatric patients in the prone position, the reliability of pulse pressure variation and stroke volume variation, and pleth variability index to predict fluid responsiveness have not previously been established. Perioperatively, in this setting, optimizing fluid management can be challenging, and fluid overload is associated with both intraoperative and postoperative complications. The investigator designed this study to assess the sensitivity and specificity of baseline PPV, SVV, and PVI the tidal volume (VT) challenge (VTC) and in predicting fluid responsiveness during elective neurosurgery.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-07
• Study First Submitted: 2022-07-04
• Study First Submitted QC: 2022-07-04
• Study First Posted: 2022-07-08
• Last Update Submitted: 2022-07-10
• Study Start: 2022-07-12
• Last Update Posted: 2022-07-12
• Primary Completion: 2023-07-31
• Study Completion: 2023-07-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• elective neurosurgery and requiring prone positioning

Exclusion Criteria

• (1) chronic cardiac arrhythmia; (2) depressed left (<30% of ejection fraction) (3) patients with pulmonary disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
fluid responsiveness prediction using AUC of ROC curve analysis	from induction of anesthesia to end of operation, about 5 hours	stroke volume index increase more than 10% from baseline after volume administration (10ml/kg) Fluid responsiveness parameters; PPV, SVV, PVI, rPVI before and after tidal volume challenge

Trial Locations

Locations (1)

Hee-Soo Kim; 🇰🇷 Seoul, Korea, Republic of