Efficacy of resuscitation in patients with sepsis using a novel ultrasound measurement (delta-carotid velocity time integral) to determine intravascular fluid replacement

Not Applicable

• Conditions: Sepsis; Emergency medicine - Resuscitation; Infection - Other infectious diseases

• Registration Number: ACTRN12620000280909
• Lead Sponsor: St Vincent's hospital Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-03-03
• Last Update Posted: 10 March 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

1) Working diagnosis of sepsis*

*Surviving sepsis 2016 definition:
Potential source of infection with 2 of:
- SBP < /= 100
- RR >/= 22
- GCS < 15

2) >/= 18y/o
3) Sinus Rhythm

Exclusion Criteria

1) Treating clinician determined contra-indication to fluid challenge
2) Concurrent vasopressin use
3) Pregnancy
4) Cardiac arrest due to severe hypotension or sepsis
5) Clinical hypervolaemia
- decompensated chronic liver disease with ascites
- nephrotic syndrome
- severe cardiomyopathy with evidence of fluid overload (elevated JVP, bilateral pedal oedema, bibasal creps)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ltrasound determined carotid velocity time integral sensitivity and specificity<br>[Approximately 30 minutes following protocol commencement];Ultrasound measured carotid blood flow sensitivity and specificity[Approximately 30 minutes following protocol commencement];Ultrasound measured carotid respiratory variation[Approximately 30 minutes following protocol commencement]

Secondary Outcome Measures

Name	Time	Method
Clinical volume responsiveness, determined by at least 10% improvement in heart rate (HR) or blood pressure (BP). Both of these vital signs will be recorded by the emergency trained nurse before and after the intervention. HR will be recorded by counting the radial pulse for 60 min and BP will be recorded using standardised automatic hospital machine. [Approximately 30 minutes following protocol commencement]