Connectome Characterization With Aging

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT03109275
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The main aim of this project is to develop a new model to characterize brain connectivity and its changes with aging. This characterization will be based on new sensitive and specific markers, allowing a better understanding of structural and functional brain networks. To this end, two complementary MRI methods will be developed: 1) Resting-state functional MRI (rs-fMRI) which allows the measurement of cerebral activity in different cortical gray matter regions, and 2) high angular resolution diffusion imaging (HARDI) MRI, which allows to characterize brain tissue microarchitecture. HARDI sequences will be developed to acquire and reconstruct fiber tractography of patient's brains. In combination with conventional MRI, both HARDI and rs-fMRI will be used to estimate the connection degree between each pair of cortical regions, so- called "Connectome". Once generated, brain networks will be quantified through numerous graph metrics, such as graph density, global efficiency and assortativity (etc.), reflecting the organization and topology of subjects' connectivity with aging.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-22
• Study First Submitted: 2017-03-01
• Study First Submitted QC: 2017-04-05
• Study First Posted: 2017-04-12
• Primary Completion: 2020-02-14
• Study Completion: 2020-02-14
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-13
• Last Update Posted: 2022-04-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Volunteers (Men and women) aged between 18 and 50 years
• No neurological or psychiatric diseases

Exclusion Criteria

• MRI contraindications
• Pregnant women or nursing women
• Persons under guardianship or any other administrative or deprivation of liberty or of right

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Functional and structural connectivity MRI marker : Diffusion tensor	End of study (one year)	Structural connectivity of white matter (WM) fiber bundles measured by diffusion tensor imaging
Functional and structural connectivity MRI marker : resting-state fMRI	End of study (one year)	Functional connectivity of grey matter (GM) using resting-state fMRI
Functional and structural connectivity MRI marker : Functional connectivity	End of study (one year)	Graph-theory methods analysis of functional connectivity of grey matter
Functional and structural connectivity MRI marker : Structural connectivity	End of study (one year)	Graph-theory methods analysis of Structural connectivity of white matter (WM) fiber
Functional and structural connectivity MRI marker : SPM software	End of study (one year)	Cortical and subcortical grey matter (GM) volumes using the SPM software

Secondary Outcome Measures

Name	Time	Method
Metrics of functional connectivity	End of study (one year)	Calculation of functional connectivity metrics using graphs theory methods

Trial Locations

Locations (1)

CH le Vinatier; 🇫🇷 Bron, France