Connectome Characterization With Aging
- Conditions
- Healthy
- Interventions
- Other: Single complete MRI intervention
- Registration Number
- NCT03109275
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
The main aim of this project is to develop a new model to characterize brain connectivity and its changes with aging. This characterization will be based on new sensitive and specific markers, allowing a better understanding of structural and functional brain networks. To this end, two complementary MRI methods will be developed: 1) Resting-state functional MRI (rs-fMRI) which allows the measurement of cerebral activity in different cortical gray matter regions, and 2) high angular resolution diffusion imaging (HARDI) MRI, which allows to characterize brain tissue microarchitecture. HARDI sequences will be developed to acquire and reconstruct fiber tractography of patient's brains. In combination with conventional MRI, both HARDI and rs-fMRI will be used to estimate the connection degree between each pair of cortical regions, so- called "Connectome". Once generated, brain networks will be quantified through numerous graph metrics, such as graph density, global efficiency and assortativity (etc.), reflecting the organization and topology of subjects' connectivity with aging.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Volunteers (Men and women) aged between 18 and 50 years
- No neurological or psychiatric diseases
- MRI contraindications
- Pregnant women or nursing women
- Persons under guardianship or any other administrative or deprivation of liberty or of right
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Single MRI examination Single complete MRI intervention 40 subjects will benefit from a full MRI Reproducibility study Single complete MRI intervention 10 subjects will benefit from the realization of 3 MRI. An MRI examination performed at the time of inclusion and then an examination, at 3 months and at 9 months (ie 3 examinations per subject).
- Primary Outcome Measures
Name Time Method Functional and structural connectivity MRI marker : Diffusion tensor End of study (one year) Structural connectivity of white matter (WM) fiber bundles measured by diffusion tensor imaging
Functional and structural connectivity MRI marker : resting-state fMRI End of study (one year) Functional connectivity of grey matter (GM) using resting-state fMRI
Functional and structural connectivity MRI marker : Functional connectivity End of study (one year) Graph-theory methods analysis of functional connectivity of grey matter
Functional and structural connectivity MRI marker : Structural connectivity End of study (one year) Graph-theory methods analysis of Structural connectivity of white matter (WM) fiber
Functional and structural connectivity MRI marker : SPM software End of study (one year) Cortical and subcortical grey matter (GM) volumes using the SPM software
- Secondary Outcome Measures
Name Time Method Metrics of functional connectivity End of study (one year) Calculation of functional connectivity metrics using graphs theory methods
Trial Locations
- Locations (1)
CH le Vinatier
🇫🇷Bron, France