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Connectome Characterization With Aging

Not Applicable
Completed
Conditions
Healthy
Interventions
Other: Single complete MRI intervention
Registration Number
NCT03109275
Lead Sponsor
Hospices Civils de Lyon
Brief Summary

The main aim of this project is to develop a new model to characterize brain connectivity and its changes with aging. This characterization will be based on new sensitive and specific markers, allowing a better understanding of structural and functional brain networks. To this end, two complementary MRI methods will be developed: 1) Resting-state functional MRI (rs-fMRI) which allows the measurement of cerebral activity in different cortical gray matter regions, and 2) high angular resolution diffusion imaging (HARDI) MRI, which allows to characterize brain tissue microarchitecture. HARDI sequences will be developed to acquire and reconstruct fiber tractography of patient's brains. In combination with conventional MRI, both HARDI and rs-fMRI will be used to estimate the connection degree between each pair of cortical regions, so- called "Connectome". Once generated, brain networks will be quantified through numerous graph metrics, such as graph density, global efficiency and assortativity (etc.), reflecting the organization and topology of subjects' connectivity with aging.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
10
Inclusion Criteria
  • Volunteers (Men and women) aged between 18 and 50 years
  • No neurological or psychiatric diseases
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Exclusion Criteria
  • MRI contraindications
  • Pregnant women or nursing women
  • Persons under guardianship or any other administrative or deprivation of liberty or of right
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Single MRI examinationSingle complete MRI intervention40 subjects will benefit from a full MRI
Reproducibility studySingle complete MRI intervention10 subjects will benefit from the realization of 3 MRI. An MRI examination performed at the time of inclusion and then an examination, at 3 months and at 9 months (ie 3 examinations per subject).
Primary Outcome Measures
NameTimeMethod
Functional and structural connectivity MRI marker : Diffusion tensorEnd of study (one year)

Structural connectivity of white matter (WM) fiber bundles measured by diffusion tensor imaging

Functional and structural connectivity MRI marker : resting-state fMRIEnd of study (one year)

Functional connectivity of grey matter (GM) using resting-state fMRI

Functional and structural connectivity MRI marker : Functional connectivityEnd of study (one year)

Graph-theory methods analysis of functional connectivity of grey matter

Functional and structural connectivity MRI marker : Structural connectivityEnd of study (one year)

Graph-theory methods analysis of Structural connectivity of white matter (WM) fiber

Functional and structural connectivity MRI marker : SPM softwareEnd of study (one year)

Cortical and subcortical grey matter (GM) volumes using the SPM software

Secondary Outcome Measures
NameTimeMethod
Metrics of functional connectivityEnd of study (one year)

Calculation of functional connectivity metrics using graphs theory methods

Trial Locations

Locations (1)

CH le Vinatier

🇫🇷

Bron, France

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