Technical Development of Multi-Parametric Renocerebral MRI

Recruiting

• Conditions: Aging
• Interventions: Other: Group 4; Other: MRI

• Registration Number: NCT02831335
• Lead Sponsor: University of Minnesota

Brief Summary

The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-06-15
• Study First Submitted QC: 2016-07-08
• Study First Posted: 2016-07-13
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-31
• Last Update Posted: 2024-11-04
• Study Start: 2026-12-01
• Primary Completion: 2030-12-31
• Study Completion: 2032-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. English-speaking as primary language
2. No hearing loss or uncorrected vision

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Exclusion Criteria

1. Lacking capacity to consent
2. Having known history of cardiovascular diseases (e.g., clinical stroke)
3. Having acute and chronic obstructive pulmonary disease
4. Having known history of renal diseases (e.g., acute kidney injury)
5. Having known history of cognitive disorder or psychiatric illness
6. Having known history of chemical dependence (e.g., alcohol and narcotics)
7. Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 4	Group 4	normal 66- 80 years old participants
Group 1	MRI	normal 21-35 years old participants
Group 2	MRI	normal 36-50 years old participants
Group 3	MRI	normal 51-65 years old participants

Primary Outcome Measures

Name	Time	Method
Cognitive performance for each group	Baseline	The total cognitive performance scores will be summarized for each group by using mean and standard deviation or standard error.
MRI measured vascular reactivity for each group	Baseline	MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
MRI measured perfusion for each group	Baseline	MRI measurements will be summarized for each group by using mean and standard deviation or standard error.

Trial Locations

Locations (1)

Center for Magnetic Resonance Research; 🇺🇸 Minneapolis, Minnesota, United States