Understanding How Anaesthesia Affects ECT Outcomes

Phase 3

Completed

• Conditions: Depression
• Interventions: Other: Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)

• Registration Number: NCT03105245
• Lead Sponsor: The University of New South Wales

Brief Summary

This study will examine how anaesthetic technique affects ECT outcomes. Specifically, the investigators will examine how: 1) the time interval between anaesthetic and ECT stimulus, and 2) the ventilation rate before ECT stimulus, impacts on the quality of the EEG (this is a recording of brain activity during ECT and is used to judge the quality of a seizure and to guide individual patient dosing).

Detailed Description

This study aims to examine how the time interval between administration of anaesthetic agent and ECT stimulus delivery impacts upon measures of EEG quality (seizure quality).

Study Timeline

• Study First Submitted: 2017-02-27
• Study Start: 2017-03-15
• Study First Submitted QC: 2017-04-02
• Study First Posted: 2017-04-07
• Primary Completion: 2019-03-15
• Study Completion: 2019-03-15
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-28
• Last Update Posted: 2023-03-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Patients treated with a course of ECT

Exclusion Criteria

• Use of non-standard anaesthetic agents in ECT (e.g. ketamine)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Short time interval + Normal ventilation	Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)	-
Short time interval + Hyperventilation	Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)	-
Long time interval + Normal ventilation	Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)	-
Long time interval + Hyperventilation	Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)	-

Primary Outcome Measures

Name	Time	Method
EEG Seizure Quality Rating using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al	Outcome measures will be collected immediately after each ECT treatment from the first treatment until the end of the ECT course, an estimated total of four to six weeks for most participants	EEG quality will be rated manually for each ECT treatment undertaken by a participant until the conclusion of their ECT course. This rating will be done using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al - low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy; Journal of Affective Disorders, 2010; 126: 330-333

Trial Locations

Locations (1)

Wesley Hospital Kogarah; 🇦🇺 Sydney, New South Wales, Australia