EEG mu-rhythm analysis of mirror neuron activity in tremor-dominant and PIGD-dominant Parkinson*s disease patients.

Completed

Conditions: Parkinson's disease
10028037

Registration Number: NL-OMON32519

Lead Sponsor: Medisch Spectrum Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 15

Inclusion Criteria

Patients with Parkinson*s disease diagnosis according to the UK Brain Bank criteria Besides having PD, patients are in good physical condition
Patients must be able to concentrate for short periods of time

Exclusion Criteria

Patients who cannot fully cooperate during the experiments
Parkinson patients who are not classified as either tremor dominant or PIGD-dominant
Parkinson patient with implanted deep brain stimulator
Patients suffering from dementia
Patients suffering from severe tremors or dyskinesias, that interfere with the EEG recording
People using sedative medication

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters will be EEG amplitude (depends on event-related<br /><br>(de)synchronization (ERD/ERS)) and frequency around the mirror neuron areas<br /><br>(C3/C4 of standard EEG electrode lay-out). The parameters are observed for<br /><br>three conditions: the different hand movement videos, the execution of<br /><br>different hand movements by the subject, and baseline (no images and no<br /><br>movements) period. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Unintentional movement of the hand during movie observation and eye blinking<br /><br>can intervene with the EEG results. Therefore, eye blinking and unintentional<br /><br>hand movements need to be detected.<br /><br>Unintentional hand movements, which can be tremor in Parkinson*s patients, can<br /><br>be detected by 3D inertial sensors. Eye blinking can be registered by<br /><br>monitoring the most frontal EEG electrodes. </p><br>