A comparative study of sympathoadrenal stress response modulation by intravenous versus nebulised dexmedetomidine during laryngoscopy and endotracheal intubation. A prospective randomised trial
- Conditions
- Health Condition 1: O- Medical and Surgical
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients aged 18-60 years of either sex , ASA physical status I/II , Duration surgical procedures Undergoing short (parotidectomy, thyroidectomy, dental extractions, laparoscopic cholecystectomy) extending up to 2 hours will be enrolled in the study. (Duration of surgery was decided based upon the elimination half-life of the shorter acting of the two drugs involved in the study, in this case being dexmedetomidine (Elimination t1/2 -2 hrs))
Patient refusal, Hypersensitivity to the drugs being evaluated, History of pre-operative sore throat, Upper respiratory tract infection, Pregnancy, Chronic obstructive pulmonary disease/ Asthmatic patients, Cardiac patients, Hepatic/renal disease, Mallampatti grade >2, Body Mass Index (BMI) more than 40 kg/m2, Predicted difficult airway or unanticipated difficult intubation and those requiring laryngoscopy more than 15 secs or two attempts or more, Chronic use of opioids/opioid addiction, steroids, Inability to comprehend postoperatively neuropsychiatric disorders, Preoperative drugs that could be potential confounders (clonidine, gabapentin, pregabalin and steroids)
The enlisted patients, who needed more than one intubation attempt or developed any intra-operative or post-operative complication included unanticipated change in surgical plan or increase in the duration of surgery were also excluded from further evaluation and analysis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in heart rate, mean arterial pressures upon laryngoscopy and intubation as compared to pre laryngoscopy/ intubation and baseline levelsTimepoint: 0, 1min, 3 min, 5 min, 7 min, 10 min, 15 min, 30min, 45 min, 60 min, 75 min, 90 min, 105 min, 120 min
- Secondary Outcome Measures
Name Time Method Compare effects of these routes on intraoperative analgesic consumption and incidence and sore throat post operativelyTimepoint: Post extubation, 1 hr, 2 hr, 4 hr, 6 hr, 8 hr, 12 hr, 24 hr