Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles

Not Applicable

Withdrawn

• Conditions: Infertility; Subfertility
• Interventions: Procedure: Fresh embryo transfer; Procedure: Embryo cryopreservation

• Registration Number: NCT00736177
• Lead Sponsor: Fertility Center of Las Vegas

Brief Summary

This study seeks to determine if patients with a history of failed fresh embryo transfer(s) will have increased success rates with embryo cryopreservation and subsequent thawed embryo transfer when compared to fresh embryo transfer.

Detailed Description

Implantation failure remains a significant problem in cycles of in vitro fertilization (IVF). Patients with a history of implantation failure in fresh autologous cycles have been shown have reduced chance of success in subsequent fresh autologous cycles. A potentially frequent cause of implantation failure is reduced endometrial receptivity following ovarian stimulation, perhaps due to the effects of supraphysiologic hormone levels on endometrial development. Therefore, such patients may have a greater chance of success if all of their embryos are cryopreserved for use in a subsequent cycle in which endometrial development can be more carefully controlled, absent the effects of ovarian stimulation. Therefore this study compares success rates in cycles of fresh embryo transfer and cycles with transfer of frozen-thawed embryos.

Study Timeline

• Study Start: 2008-08
• Study First Submitted: 2008-08-13
• Study First Submitted QC: 2008-08-13
• Study First Posted: 2008-08-15
• Status Verified: 2009-02
• Primary Completion: 2009-08
• Study Completion: 2009-08
• Last Update Submitted: 2014-04-08
• Last Update Posted: 2014-04-09

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

• Age 18 to 40 years
• Cycle day 3 FSH less than 10 IU/l
• At least 8 antral follicles
• At least one previous autologous embryo transfer cycle that did not result in ongoing pregnancy at 10 weeks.

Exclusion Criteria

• Embryo biopsy
• Any prior fresh embryo transfer that resulted in live birth

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Fresh embryo transfer	Patients in the control group will undergo conventional IVF cycles with fresh blastocyst transfer.
Test group	Embryo cryopreservation	Patients in the Test group will have their embryos cryopreserved for transfer in a second cycle.

Primary Outcome Measures

Name	Time	Method
Ongoing pregnancy with fetal heart motion	10 weeks gestation

Trial Locations

Locations (1)

Fertility Center of Las Vegas; 🇺🇸 Las Vegas, Nevada, United States