Ionized Magnesium Concentration in Athletes and Exercise Induced Changes in Ionized Magnesium
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Wageningen University
- Enrollment
- 18
- Primary Endpoint
- Blood samples analyzed on the pHOx analyzer for their ionized magnesium concentration
Study Overview
Brief Summary
Ionized magnesium variation is measured during a normal day and again during a day with an exercise protocol of 90 minutes.
Detailed Description
Magnesium is an essential micronutrient for health and exercise performance. Deficiencies are common, especially in case of insufficient diets. Athletes are a population at risk of magnesium deficiency, as they can have strong nutritional (dis)believes and increased losses through sweat. That is why monitoring magnesium status in athletes is very important. Ionized magnesium is the active form of total magnesium, this value might be even more important than total magnesium. However, whether ionized magnesium is influenced by day variation is not clear yet. In addition: one bout of exercise can change magnesium status and probably ionized magnesium status. For people active in sports it is important to be aware of this variation in magnesium status, to prevent the diagnosis of false inadequate magnesium status. Therefore it is the aim of this proposal to determine whether ionized magnesium varies within one day and whether it changes after an acute bout of exercise.
Objective:
The main objective is to investigate whether ionized magnesium concentration varies during one day, and whether it is changed after one bout of exercise
Study design:
This will be a cross-over design. With screening and preliminary tests before the exercise test day and the non-exercise test day. The order in which exercise day and non-exercise day will be done, will be randomly divided between the participants.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age: 18 - 45 y
- •BMI: 18.5 - 25
- •Minimal of 5 hours of training per week, for at least 2 years
- •Used to bike, at least 5 hours per week in high season
- •No Mg and / or Ca supplementation during study
- •No blood donation, during or in the 6 weeks preliminary the study
- •Suitable veins
- •No chronic medication, with the exception of paracetamol and or birth control
- •No antibiotics in the month preliminary the study
- •Good health
- •Serum Mg > 0.7 mmol/L
- •Willing to give blood
- •Able to be present and participate at all test days
Exclusion Criteria
- •Chronical illness
- •Use of medication with the exception of paracetamol and or birth control
- •Mg and or Ca supplementation use
- •Inadequate Mg intake (according to FFQ)
- •Working at Human Nutrition
- •Wageningen University Msc thesis or internship at Human Nutrition
- •Participating in other scientific research (with the exception of EetMeetWeet)
Outcomes
Primary Outcomes
Blood samples analyzed on the pHOx analyzer for their ionized magnesium concentration
Time Frame: Blood samples are collected at 7 set time points during one day
blood
Secondary Outcomes
- blood samples are analyzed on the Dimension Vista 1500 of Siemens for their total magnesium concentration(Blood samples are collected at 7 set time points during one day)