Randomized Phase II Trial Assessing the Combination of Nexavar® (Sorafenib), and Gemcitabine/Oxaliplatin in Patients Treated for Advanced (Unresectable/Metastatic) Hepatocellular Carcinoma.
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Tumor response according to RECIST criteria
研究概览
简要总结
RATIONALE: Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as gemcitabine hydrochloride and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether sorafenib tosylate is more effective when given with or without gemcitabine hydrochloride and oxaliplatin in treating patients with liver cancer.
PURPOSE: This randomized phase II trial is studying sorafenib tosylate to see how well it works when given with or without gemcitabine hydrochloride and oxaliplatin in treating patients with locally advanced, unresectable, or metastatic liver cancer.
详细描述
OBJECTIVES:
Primary
- Assess progression-free survival (RECIST) in patients with locally advanced, unresectable or metastatic hepatocellular carcinoma treated with sorafenib tosylate with vs without gemcitabine hydrochloride and oxaliplatin.
Secondary
- Evaluate the tolerability of these regimens in these patients.
- Determine the objective response rate (RECIST) in patients treated with these regimens.
- Assess the overall survival of patients treated with these regimens.
- Evaluate the pharmacokinetics of sorafenib tosylate.
- Assess biomarkers (e.g., pERK levels) associated with treatment response.
- Assess angiogenic response by functional imaging.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 120 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Arm II
Patients receive oral sorafenib tosylate twice daily on days 1-14.
干预措施: oxaliplatin (Drug)
Arm I
Patients receive oral sorafenib tosylate as in arm I. Patients also receive gemcitabine hydrochloride IV over 100 minutes on day 1 and oxaliplatin IV over 2 hours on day 2. Treatment with gemcitabine hydrochloride and oxaliplatin repeats every 14 days for 12 courses in the absence of disease progression or unacceptable toxicity.
干预措施: sorafenib tosylate (Drug)
Arm II
Patients receive oral sorafenib tosylate twice daily on days 1-14.
干预措施: gemcitabine hydrochloride (Drug)
Arm II
Patients receive oral sorafenib tosylate twice daily on days 1-14.
干预措施: sorafenib tosylate (Drug)
结局指标
主要结局
Tumor response according to RECIST criteria
时间窗: 18 months
Progression-free survival
时间窗: 18 months
次要结局
未报告次要终点